UWA Dental School, The University of Western Australia, Perth, Western Australia, Australia.
Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
Oral Dis. 2023 Nov;29(8):3034-3048. doi: 10.1111/odi.14305. Epub 2022 Jul 22.
Head and neck cancers are a heterogeneous group of neoplasms, which together comprise the sixth most common cancer globally. Breath biopsies are a non-invasive clinical investigation that detect volatile organic compounds (VOCs) in exhaled breath. This systematic review examines current applications of breath biopsy for the diagnosis of head and neck squamous cell carcinoma (HNSCC), including data on efficacy and utility, and speculates on the future uses of this non-invasive detection method. Medline, PubMed, Web of Science, Cochrane and Scopus, as well as the grey literature were searched using a search strategy developed to identify relevant studies on the role of breath biopsy in the diagnosis of HNSCC. All included studies were subject to a thorough methodological quality assessment. The initial search generated a total of 1443 articles, 20 of which were eligible for review. A total of 660 HNSCC samples were investigated across the included studies. 3,7-dimethylundecane and benzaldehyde were among several VOCs to be significantly correlated with the presence of HNSCC compared to healthy controls. We show that current breath biopsy methods have high accuracy, specificity and sensitivity for identifying HNSCC. However, further studies are needed given the reported poor quality of the included studies.
头颈部癌症是一组异质性的肿瘤，它们共同构成了全球第六大最常见的癌症。呼吸活检是一种非侵入性的临床研究，可检测呼出呼吸中的挥发性有机化合物 (VOCs)。本系统评价检查了呼吸活检在头颈部鳞状细胞癌 (HNSCC) 诊断中的当前应用，包括关于疗效和实用性的数据，并推测了这种非侵入性检测方法的未来用途。使用专门开发的搜索策略在 Medline、PubMed、Web of Science、Cochrane 和 Scopus 以及灰色文献中搜索了相关研究，以确定呼吸活检在 HNSCC 诊断中的作用。所有纳入的研究都经过了彻底的方法学质量评估。最初的搜索总共产生了 1443 篇文章，其中 20 篇符合审查条件。纳入的研究共调查了 660 个 HNSCC 样本。与健康对照组相比，3,7-二甲基十一烷和苯甲醛等几种 VOC 与 HNSCC 的存在显著相关。我们表明，目前的呼吸活检方法对头颈部鳞状细胞癌的识别具有很高的准确性、特异性和敏感性。然而，鉴于所报告的纳入研究质量较差，还需要进一步的研究。
