Suppr超能文献

比较肿瘤整形乳房缩小术与即刻对称手术和标准乳房缩小术:术后并发症是否更严重?

Comparing oncoplastic breast reduction with immediate symmetry surgery to standard breast reduction surgery: Are postoperative complications worse?

作者信息

Pawlak Natalie, Karamchandani Manish, Wareham Carly, Gaffney Kerry, Zaccardelli Alessandra, Nardello Salvatore, Persing Sarah, Chatterjee Abhishek, Homsy Christopher

机构信息

Tufts University School of Medicine, Boston, Massachusetts, USA.

Department of Surgery, Tufts Medical Center, Boston, Massachusetts, USA.

出版信息

J Surg Oncol. 2022 Nov;126(6):956-961. doi: 10.1002/jso.27009. Epub 2022 Jul 8.

Abstract

INTRODUCTION

Oncoplastic breast reduction mammoplasty (ORM) is an excellent treatment option for women with breast cancer and macromastia undergoing breast conservation therapy. Here, we aim to better understand the risks associated with ORM compared to standard reduction mammoplasty (SRM).

METHODS

A retrospective chart review was performed of patients undergoing ORM or SRM from 2015 to 2021. Primary outcomes included the occurrence of major or minor postoperative complications in the two groups and delays to adjuvant therapy (>90 days) among the women undergoing ORM.

RESULTS

Women in the ORM group (n = 198) were significantly older (p < 0.001) with a higher prevalence of smoking (p < 0.001), diabetes mellitus (p < 0.01), and a Charlson comorbidity index ≥ 3 (p < 0.001) compared to women undergoing SRM (n = 177). After controlling for potential confounders, there were no significant between-group differences in the odds of developing postoperative complications (odds ratio = 0.80, 95% confidence interval: 0.36-1.69). Only 3% (n = 4) of the 150 women undergoing adjuvant radiation or chemotherapy experienced delays related to postoperative complications.

CONCLUSION

ORM has a similar safety profile as SRM, despite the older age and higher number of comorbidities often seen in patients undergoing ORM, and is a safe option for achieving contralateral symmetry at the time of partial mastectomy without delays to adjuvant therapy.

摘要

引言

肿瘤整形性乳房缩小成形术(ORM)是乳腺癌合并巨乳症且正在接受保乳治疗的女性的一种极佳治疗选择。在此,我们旨在更好地了解与标准乳房缩小成形术(SRM)相比,ORM相关的风险。

方法

对2015年至2021年接受ORM或SRM的患者进行回顾性病历审查。主要结局包括两组术后主要或次要并发症的发生情况,以及接受ORM的女性辅助治疗延迟(>90天)情况。

结果

与接受SRM的女性(n = 177)相比,ORM组(n = 198)的女性年龄显著更大(p < 0.001),吸烟(p < 0.001)、糖尿病(p < 0.01)患病率更高,且Charlson合并症指数≥3(p < 0.001)。在控制潜在混杂因素后,两组术后发生并发症的几率无显著组间差异(优势比 = 0.80,95%置信区间:0.36 - 1.69)。在150名接受辅助放疗或化疗的女性中,只有3%(n = 4)因术后并发症出现治疗延迟。

结论

尽管接受ORM的患者通常年龄较大且合并症较多,但ORM与SRM具有相似的安全性,并且是在保乳手术时实现对侧对称且不延迟辅助治疗的安全选择。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验