Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung, Taiwan.
Medicine (Baltimore). 2022 Jul 8;101(27):e29918. doi: 10.1097/MD.0000000000029918.
We retrospectively analyzed 82 adult patients with MALA admitted to the ICU over 20 years. The association between the clinical parameters and mortality post-MALA was estimated using logistic regression analysis.
Patients with MALA admitted to the ICU presented with clinical symptoms mainly associated with the head (40.24%), chest (41.46%), and abdomen (35.37%). Additionally, the PLL distribution significantly varied with age, APACHE II = Acute Physiology and Chronic Health Evaluation II (APACHE II) score, various laboratory parameters like nadir arterial bicarbonate level, multiple treatment modalities such as renal replacement therapy, and mortality. The overall mortality rate was 17.07%. After adjustment of age and gender, the significant predictors of mortality were APACHE II score, PLL, vasoactive support, ventilator support, and cardiopulmonary resuscitation.
Despite MALA being a rare event, it is necessary to evaluate its clinical characteristics, especially the associated PLL and mortality. In the current study, higher levels of APACHE II score and PLL show a greater likelihood of mortality in MALA patients.
我们回顾性分析了 20 多年来 ICU 收治的 82 例成人 MALA 患者。使用逻辑回归分析评估 MALA 后临床参数与死亡率之间的关系。
入住 ICU 的 MALA 患者主要出现与头部（40.24%）、胸部（41.46%）和腹部（35.37%）相关的临床症状。此外，PLL 分布与年龄、急性生理学与慢性健康评估 II 评分（APACHE II）、最低动脉碳酸氢盐水平等各种实验室参数、肾脏替代治疗等多种治疗方式以及死亡率显著相关。总的死亡率为 17.07%。在调整年龄和性别后，死亡率的显著预测因子为 APACHE II 评分、PLL、血管活性支持、呼吸机支持和心肺复苏。
尽管 MALA 是一种罕见事件，但仍有必要评估其临床特征，尤其是相关的 PLL 和死亡率。在本研究中，较高的 APACHE II 评分和 PLL 水平表明 MALA 患者的死亡率更高。
