Division of Gastroenterology, Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of Korea.
Medicine (Baltimore). 2022 Jul 8;101(27):e29493. doi: 10.1097/MD.0000000000029493.
Colorectal cancer is a common cancer; generally, adults aged ≥ 50 years are screened using stool occult blood tests and colonoscopy. However, colorectal adenoma and cancer have been found in patients under the aged of 50, and studies on characteristics and risk factors in young patients are lacking. We evaluated the prevalence and risk factors of colorectal adenoma and cancer in young adults aged under 50 years. We retrospectively analyzed 570 individuals aged under 50 years who underwent colonoscopy at the Haeundae Paik Hospital, Korea, from January to June 2018. Logistic regression model was used to identify the risk factors for colorectal adenoma and colorectal cancer. The prevalence of colorectal adenoma in group of 19-29 years was 3.2% (1 of 31), 30-39 years was 13.8% (30 of 217) and in the group of 40-49 years was 21.1% (68 of 322) (P = .009). In multivariable analysis, age over 45 years (adjusted odds ratio [OR], 1.941; 95% confidence interval [CI], 1.187-3.172; P = .008) and male sex (adjusted OR, 1.711; 95% CI, 1.044-2.806; P = .033) were independent risk factors for colorectal neoplasia including cancer. The prevalence of colorectal adenoma increases as the age increased in young adults under 50 years of age, especially after the age of 45 years, the risk of colorectal neoplasia increases; hence, early screening should be considered before the age of 50 years.
结直肠癌是一种常见的癌症；一般来说，≥50 岁的成年人使用粪便潜血试验和结肠镜检查进行筛查。然而，在 50 岁以下的患者中已经发现了结直肠腺瘤和癌症，并且缺乏对年轻患者特征和危险因素的研究。我们评估了年龄在 50 岁以下的年轻成年人中结直肠腺瘤和癌症的患病率和危险因素。我们回顾性分析了 2018 年 1 月至 6 月在韩国海云台白医院接受结肠镜检查的 570 名年龄在 50 岁以下的个体。使用逻辑回归模型确定结直肠腺瘤和结直肠癌的危险因素。19-29 岁组结直肠腺瘤的患病率为 3.2%（31 例中的 1 例），30-39 岁组为 13.8%（217 例中的 30 例），40-49 岁组为 21.1%（322 例中的 68 例）（P =.009）。多变量分析显示，年龄超过 45 岁（调整优势比[OR]，1.941；95%置信区间[CI]，1.187-3.172；P =.008）和男性（调整 OR，1.711；95%CI，1.044-2.806；P =.033）是结直肠肿瘤包括癌症的独立危险因素。在 50 岁以下的年轻成年人中，结直肠腺瘤的患病率随着年龄的增长而增加，尤其是在 45 岁以后，结直肠肿瘤的风险增加；因此，应考虑在 50 岁之前进行早期筛查。
