Dang Luan Minh, Le Nhan Quang, Le Huy Minh, Vo Diem Thi-Ngoc, Vuong Nguyen Lam, Duong Minh Cuong, Quach Duc Trong
Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam.
Medicine (Baltimore). 2025 Jul 4;104(27):e43222. doi: 10.1097/MD.0000000000043222.
Research on the prevalence of adenomas and colorectal cancer (CRC) in individuals aged 50 years or younger with first-degree relatives diagnosed with early-onset colorectal advanced adenoma (E-CAA), defined as the onset of colorectal advanced adenoma (CAA) at or before 50 years of age, is scarce. We examined the prevalence of colorectal neoplasia among siblings aged 50 years or younger of E-CAA patients. A cross-sectional study was conducted at the University Medical Center in Ho Chi Minh City, Vietnam. Study participants included 96 siblings aged 50 years or younger from 58 E-CAA patients, who were selected from a total of 732 identified siblings, with a notably high rate of participation refusal. All included siblings were either older than the patients diagnosed with E-CAA or younger by no more than10 years. Individuals with a family history of CRC were excluded from this study. All siblings underwent standard bowel preparation and colonoscopies. The mean age of siblings was 40.9 ± 6.0 years, with males comprising 47.9%. Most of the siblings (83.3%) were asymptomatic. The prevalence of colorectal neoplasia among the siblings was 25%. Of these, 95.8% were adenomas, and CRC was identified in one sibling. The proportion of CAA and advanced colorectal neoplasia was 6.3% and 7.3%, respectively. These proportions increased to 13% and 15.2%, respectively, among the male siblings. None of the female siblings were diagnosed with CAA or advanced colorectal neoplasia. No statistically significant difference was observed in the prevalence of colorectal neoplasia (23.7% vs 25.9%, P = .81), CAA (5.3% vs 6.9%, P > .99), or advanced colorectal neoplasia (7.9% vs 6.9%, P > .99) between sibling age groups (40 years or 40-50 years). Colorectal neoplasia is not uncommon in siblings aged ≤ 50 years of E-CAA patients. The prevalence of CAA and advanced colorectal neoplasia is markedly elevated in male siblings. These high-risk individuals may benefit from early targeted colorectal cancer screening.
关于50岁及以下且一级亲属被诊断为早发性结直肠高级别腺瘤（E-CAA，定义为50岁及以前发生的结直肠高级别腺瘤）的个体中腺瘤和结直肠癌（CRC）患病率的研究很少。我们调查了E-CAA患者50岁及以下兄弟姐妹中结直肠肿瘤的患病率。在越南胡志明市的大学医学中心进行了一项横断面研究。研究参与者包括来自58例E-CAA患者的96名50岁及以下的兄弟姐妹，这些患者是从总共732名已识别的兄弟姐妹中挑选出来的，参与拒绝率非常高。所有纳入的兄弟姐妹要么比被诊断为E-CAA的患者年龄大，要么比其小不超过10岁。有CRC家族史的个体被排除在本研究之外。所有兄弟姐妹均接受了标准的肠道准备和结肠镜检查。兄弟姐妹的平均年龄为40.9±6.0岁，男性占47.9%。大多数兄弟姐妹（83.3%）无症状。兄弟姐妹中结直肠肿瘤的患病率为25%。其中，95.8%为腺瘤，在一名兄弟姐妹中发现了CRC。CAA和晚期结直肠肿瘤的比例分别为6.3%和7.3%。在男性兄弟姐妹中，这些比例分别增至13%和15.2%。没有女性兄弟姐妹被诊断为CAA或晚期结直肠肿瘤。在兄弟姐妹年龄组（40岁或40 - 50岁）之间，结直肠肿瘤（23.7%对25.9%，P = 0.81）、CAA（5.3%对6.9%，P > 0.99）或晚期结直肠肿瘤（7.9%对6.9%，P > 0.99）的患病率未观察到统计学上的显著差异。在E-CAA患者50岁及以下的兄弟姐妹中，结直肠肿瘤并不罕见。男性兄弟姐妹中CAA和晚期结直肠肿瘤的患病率明显升高。这些高危个体可能受益于早期针对性的结直肠癌筛查。
