Research Collaboratory for Structural Bioinformatics Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, U.S.A.
Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, U.S.A.
Emerg Top Life Sci. 2022 Sep 9;6(3):231-243. doi: 10.1042/ETLS20210267.
The symmetry of biological molecules has fascinated structural biologists ever since the structure of hemoglobin was determined. The Protein Data Bank (PDB) archive is the central global archive of three-dimensional (3D), atomic-level structures of biomolecules, providing open access to the results of structural biology research with no limitations on usage. Roughly 40% of the structures in the archive exhibit some type of symmetry, including formal global symmetry, local symmetry, or pseudosymmetry. The Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (founding member of the Worldwide Protein Data Bank partnership that jointly manages, curates, and disseminates the archive) provides a variety of tools to assist users interested in exploring the symmetry of biological macromolecules. These tools include multiple modalities for searching and browsing the archive, turnkey methods for biomolecular visualization, documentation, and outreach materials for exploring functional biomolecular symmetry.
自血红蛋白结构确定以来，生物分子的对称性一直令结构生物学家着迷。蛋白质数据库 (PDB) 档案是三维（3D）、生物分子原子水平结构的全球中央档案库，为结构生物学研究成果提供开放获取，无使用限制。档案库中约有 40%的结构表现出某种类型的对称性，包括正式的全局对称性、局部对称性或伪对称性。研究合作生物信息学结构学 (RCSB) 蛋白质数据库（全球蛋白质数据库合作伙伴关系的创始成员，共同管理、维护和传播档案）提供了各种工具来帮助有兴趣探索生物大分子对称性的用户。这些工具包括用于搜索和浏览档案的多种模式、用于生物分子可视化的即用型方法，以及用于探索功能生物分子对称性的文档和推广材料。
