Department of Chemistry, Maulana Azad of Arts, Science and Commerce, Aurangabad, India.
Department of Chemistry, Faculty of Education-Albaydha, Albaydha University, Albaydha, Yemen.
Nat Prod Res. 2023 Mar;37(6):1016-1022. doi: 10.1080/14786419.2022.2097227. Epub 2022 Jul 8.
Liquid Chromatography-Mass Spectrometry (LC-MS) analysis of methanol extract of seed revealed the presence of haploperozide and austricine. For safety, heavy metals content investigation of plant powder using the Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) technique showed that the toxic metals (Pb: 2.07 mg/kg; Cd: 0.07 mg/kg; and As: 0.18 mg/kg) concentrations were found to be below the permissible limit. The extract demonstrated significant antibacterial activity against (MIC value 125 g/mL). Furthermore, it was effective in inhibiting both α-glucosidase and α-amylase enzymes with a high percentage and IC values were 42.28 ± 0.39 µg/mL and 34.11 ± 0.31 µg/mL, respectively. These findings were supported by a molecular docking study, some of the phytochemicals showed higher docking score values than references. However, seeds are safe to consume because they contain low levels of toxic heavy metals and possess antibacterial and anti-diabetic properties.
对种子甲醇提取物的液相色谱-质谱（LC-MS）分析表明，存在哈普洛佩罗兹和奥斯特林。为了安全起见，使用电感耦合等离子体质谱（ICP-MS）技术对植物粉末中的重金属含量进行了调查，结果表明，有毒金属（Pb：2.07mg/kg；Cd：0.07mg/kg；As：0.18mg/kg）的浓度低于允许限量。提取物对 表现出显著的抗菌活性（MIC 值为 125μg/mL）。此外，它还能有效抑制α-葡萄糖苷酶和α-淀粉酶，抑制率高，IC 值分别为 42.28±0.39μg/mL 和 34.11±0.31μg/mL。这些发现得到了分子对接研究的支持，一些植物化学物质的对接评分值高于对照物。然而， 种子是安全可食用的，因为它们含有低水平的有毒重金属，具有抗菌和抗糖尿病特性。
