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核心技术专利：CN118964589B侵权必究
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生物评价、植物化学成分筛检与叶提取物载入纳米粒子的制作。

Biological Evaluation, Phytochemical Screening, and Fabrication of Leaves Extract-Loaded Nanoparticles.

机构信息

Department of Biochemistry, University of Malakand, Lower Dir, Chakdara 18800, Pakistan.

Department of Chemistry, University of Malakand, Lower Dir, Chakdara 18800, Pakistan.

出版信息

Molecules. 2022 Jul 23;27(15):4707. doi: 10.3390/molecules27154707.

DOI:10.3390/molecules27154707
PMID:35897890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9369860/
Abstract

is a medicinally important plant, and by virtue of its rich phytochemical composition, this plant is widely used as essential component in traditional medication systems. Due to its wide range of medicinal applications, the extract-loaded chitosan (Ext+Ch), extract-loaded PEG (Ext+PEG), and extract-loaded locust bean gum (Ext+LGB) nanoparticles (NPs) were prepared in the present study. The prepared NPs were then evaluated for their antibacterial, antioxidant, and antidiabetic potentials. Antibacterial activities of the crude extract and the synthesized NPs were performed following standard procedures reported in the literature. The antioxidant capabilities of extract and NPs were evaluated using DPPH free radical scavenging assay. The antidiabetic potential of the samples was evaluated against α-amylase and α-glucosidase. Ext+PEG NPs showed more potent antibacterial activity against the selected strains of bacteria with the highest activity against . The lowest antibacterial potential was observed for Ext+LGB NPs. The Ext+LGB NPs IC value of 39 μg/mL was found to be the most potent inhibitor of DPPH free radicals. Ext+LGB NPs showed a greater extent of inhibition against α-glucosidase and α-amylase with an IC of 83 and 78 μg/mL, whereas for the standard acarbose the IC values recorded against the mentioned enzymes were 69 and 74 μg/mL, respectively. A high concentration of phenolics and flavonoids in the crude extract was confirmed through TPC and TFC tests, HPLC profiling, and GC-MS analysis. It was considered that the observed antibacterial, antidiabetic, and antioxidant potential might be due the presence of these phenolics and flavonoids detected. The plant could thus be considered as a potential candidate to be used as a remedy of the mentioned health complications. However, further research in this regard is needed to isolate the exact responsible compounds of the observed biological potentials exhibited by the crude extract. Further, toxicity and pharmacological evaluations in animal models are also needed to establish the safety or toxicity profile of the plant.

摘要

是一种药用价值很高的植物，由于其丰富的植物化学成分，这种植物被广泛用作传统药物体系的重要成分。由于其广泛的药用应用，本研究制备了负载提取物的壳聚糖（Ext+Ch）、负载提取物的聚乙二醇（Ext+PEG）和负载提取物的刺槐豆胶（Ext+LGB）纳米粒子（NPs）。然后，评估了所制备的 NPs 的抗菌、抗氧化和抗糖尿病潜力。按照文献中报道的标准程序进行粗提物和合成 NPs 的抗菌活性测试。使用 DPPH 自由基清除测定法评估提取物和 NPs 的抗氧化能力。评估样品对α-淀粉酶和α-葡萄糖苷酶的抗糖尿病潜力。Ext+PEG NPs 对选定的细菌菌株表现出更强的抗菌活性，对 的活性最高。Ext+LGB NPs 的抗菌活性最低。Ext+LGB NPs 的 IC 值为 39 μg/mL，是最有效的 DPPH 自由基抑制剂。Ext+LGB NPs 对α-葡萄糖苷酶和α-淀粉酶的抑制作用更强，IC 值分别为 83 和 78 μg/mL，而标准阿卡波糖对上述两种酶的 IC 值分别为 69 和 74 μg/mL。通过 TPC 和 TFC 测试、HPLC 分析和 GC-MS 分析证实，粗提取物中含有高浓度的酚类和类黄酮。认为观察到的抗菌、抗糖尿病和抗氧化潜力可能是由于存在这些酚类和类黄酮。因此，该植物可以被认为是一种有潜力的候选药物，可用于治疗上述健康并发症。然而，需要在这方面进行进一步的研究，以分离出粗提取物中表现出的观察到的生物潜力的确切责任化合物。此外，还需要在动物模型中进行毒性和药理学评估，以确定该植物的安全性或毒性特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/4051cedad527/molecules-27-04707-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/b7e567083dab/molecules-27-04707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/77bfe72e0d2f/molecules-27-04707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/797053ea5982/molecules-27-04707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/835b82fa6c8c/molecules-27-04707-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/391ebf203265/molecules-27-04707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/36fa7aadc3d5/molecules-27-04707-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/c40503c9fa89/molecules-27-04707-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/4051cedad527/molecules-27-04707-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/b7e567083dab/molecules-27-04707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/77bfe72e0d2f/molecules-27-04707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/797053ea5982/molecules-27-04707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/835b82fa6c8c/molecules-27-04707-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/391ebf203265/molecules-27-04707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/36fa7aadc3d5/molecules-27-04707-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/c40503c9fa89/molecules-27-04707-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedf/9369860/4051cedad527/molecules-27-04707-g008.jpg

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