Independent Consultant, Colorado Springs, CO, USA.
Department of Pathology; 9968University of Alabama at Birmingham, Birmingham, AL, USA.
Altern Lab Anim. 2022 Jul;50(4):265-274. doi: 10.1177/02611929221107933. Epub 2022 Jul 8.
While laboratory animals are necessary for some aspects of the development of scientific and biomedical advances, including those of precision medicine, the use of human tissues is necessary in order to explore the findings and ensure that they are relevant to human systems. Many sources of human tissues exist, but researchers - particularly those making the transition from animal to human systems - may not be aware of how best to find quality sources of human tissues or how best to use them in their research. In this article, we discuss the advantages of using human tissues in research. In addition, we highlight some of the major advances made possible through the use of human tissue, and describe how human tissue is collected for research. We discuss the various types of bioresources that make human tissue available, and advise on how investigators can find and use appropriate bioresources to support their research - with the hope that this information will help facilitate the transition from research on animals to research using human tissues, as rapidly as is practicable.
虽然实验室动物对于某些科学和生物医学进展的发展是必要的，包括精准医学的发展，但为了探索发现并确保其与人类系统相关，使用人类组织是必要的。存在许多来源的人类组织，但研究人员——特别是那些从动物系统向人类系统过渡的研究人员——可能不知道如何最好地找到高质量的人类组织来源，也不知道如何在他们的研究中最好地使用这些组织。在本文中，我们讨论了在研究中使用人类组织的优势。此外，我们强调了通过使用人类组织实现的一些主要进展，并描述了如何收集人类组织用于研究。我们讨论了使人类组织可用的各种类型的生物资源，并就研究人员如何找到和使用适当的生物资源来支持他们的研究提供建议——希望这些信息将有助于促进从动物研究向使用人类组织的研究的快速过渡，只要在实践中是可行的。
