Riccardi T, Passeri F, Locatelli F
Minerva Med. 1978 Sep 15;69(42):2873-8.
A double-blind clinical trial of vincamine hydrochloride and a known dihydrogenated ergotoxine derivative, administered i.m. for 10 days, was conducted on 2 groups of 10 hospitalised cerebrovascular patients. Hemiplegia was evaluated prior to treatment and on its 5th and 10th day, by a scoring system. Statistical assessment of the results and the clinical observations showed that vincamine hydrochloride can be usefully employed in the treatment of acute cerebrovascular accidents on account of its marked effectiveness and rapid action--these being attributable to its cerebral vasoregulatory and metabolic mechanism, and to increased availability due to salification of the basic molecule--, coupled with its excellent local and general tolerability.
对两组各10名住院脑血管患者进行了一项双盲临床试验,给予盐酸长春胺和一种已知的二氢麦角毒碱衍生物,肌肉注射,为期10天。在治疗前以及治疗第5天和第10天,通过评分系统对偏瘫进行评估。结果的统计评估和临床观察表明,盐酸长春胺因其显著的有效性和快速作用而可有效用于治疗急性脑血管意外——这些归因于其脑血管调节和代谢机制,以及由于碱性分子成盐而增加的可利用性——,再加上其优异的局部和全身耐受性。