纳布啡在全身麻醉患者中的处置情况。

Disposition of nalbuphine in patients undergoing general anaesthesia.

作者信息

Sear J W, Keegan M, Kay B

出版信息

Br J Anaesth. 1987 May;59(5):572-5. doi: 10.1093/bja/59.5.572.

DOI:10.1093/bja/59.5.572

Abstract

The pharmacokinetics of nalbuphine 20 mg i.v. were studied in 10 patients undergoing lower abdominal or body surface surgery. Blood sampling was carried out for 600 min after injection and drug concentrations were measured by HPLC using electrochemical detection. Disposition was best described as a triexponential function, with a mean elimination half-life of 135.5 min. Mean residence time, clearance, and volumes of distribution, Vss and V beta, were determined by a model independent method, and gave mean values of 149.7 min (MRT), 1095 ml min-1 (ClP), 159.9 litre (Vss) and 207.1 litre (V beta).

摘要

对10例接受下腹部或体表手术的患者研究了静脉注射20毫克纳布啡的药代动力学。注射后进行600分钟的血样采集，并采用高效液相色谱电化学检测法测定药物浓度。处置过程最好用三指数函数描述，平均消除半衰期为135.5分钟。通过模型独立法测定平均驻留时间、清除率和分布容积（稳态分布容积和β相分布容积），其平均值分别为149.7分钟（平均驻留时间）、1095毫升/分钟（血浆清除率）、159.9升（稳态分布容积）和207.1升（β相分布容积）。