Reid P G, Watt A H, Penny W J, Newby A C, Smith A P, Routledge P A
Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Eur J Clin Pharmacol. 1991;40(2):175-80. doi: 10.1007/BF00280073.
Intravenous infusion of the nucleoside adenosine stimulates respiration, probably at least partly by an action in the carotid bodies, and also potentiates the ventilatory response to hypoxia, suggesting that it might be involved in the control of breathing. Whether the effects of adenosine occur at concentrations likely to be achieved in vivo is unknown and was investigated in 7 patients with arterial catheters inserted for diagnostic purposes. During intravenous infusion of adenosine (Maximum dose per min: mean 130 micrograms kg-1) mean minute ventilation increased from 5.5 to 10.9 l min-1 while mean plasma adenosine concentration in the aortic arch increased from 0.07 to 1.2 microM. In 3 patients ventilation first increased without a detectable increase in aortic adenosine concentration, suggesting a possible intra-pulmonary effect of adenosine, although increased concentrations were apparent at higher doses. Micromolar concentrations of adenosine are probably achieved in vivo in tissues during hypoxia. The present results show that at such concentrations adenosine stimulates respiration and are consistent with the suggestion that adenosine release may mediate or modulate the ventilatory response to hypoxia. A possible intra-pulmonary effect of adenosine merits further study.
静脉输注核苷腺苷可刺激呼吸，这可能至少部分是通过作用于颈动脉体实现的，并且还能增强对低氧的通气反应，这表明它可能参与呼吸控制。腺苷的这些作用是否在体内可能达到的浓度下发生尚不清楚，我们对7名因诊断目的而插入动脉导管的患者进行了研究。在静脉输注腺苷期间（每分钟最大剂量：平均130微克/千克），平均每分钟通气量从5.5升/分钟增加到10.9升/分钟，而主动脉弓中的平均血浆腺苷浓度从0.07微摩尔/升增加到1.2微摩尔/升。在3名患者中，通气首先增加，而主动脉腺苷浓度没有可检测到的增加，这表明腺苷可能存在肺内效应，尽管在更高剂量下浓度增加明显。在低氧期间，体内组织中可能会达到微摩尔浓度的腺苷。目前的结果表明，在这样的浓度下腺苷会刺激呼吸，这与腺苷释放可能介导或调节对低氧的通气反应的观点一致。腺苷可能存在的肺内效应值得进一步研究。
