Cardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi 710061, China.
Department of Reproduction Gynecology, Northwest Women and Children's Hospital, Xi'an, Shaanxi 710061, China.
Aging (Albany NY). 2022 Jul 8;14(13):5590-5610. doi: 10.18632/aging.204171.
Protein tyrosine phosphatase, non-receptor type 11 (PTPN11) is a multifunctional tyrosine phosphatase and has a significant part in many types of tumors. As of yet, neither the expression profile of PTPN11 nor its significance in pan-cancer diagnosis has been clarified. With the assistance of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), we have comprehensively mapped the expression profiles, prognostic significance, genetic alteration, phosphorylation status, infiltration of immune cells, and functional properties of PTPN11 in 33 human tumors. There was an inconsistent expression of in different tumors, and the alteration of expression predicted the survival outcomes of cancer patients. A significant association was found between the genetic alteration levels of and some tumor predictions. Besides, the reduced PTPN11 phosphorylation levels were observed in breast cancer, clear cell RCC, head and neck carcinoma, and lung adenocarcinoma (LUAD). Furthermore, there was a significant association between expression and infiltration of cancer-associated fibroblasts and endothelial cells, along with tumor mutation burden, microsatellite instability, mismatch repair genes, and immunoregulators. Finally, pathway enrichment analysis demonstrated that PTPN11-associated terms and pathways were involved in malignancy. Taken together, PTPN11 may become a new biomarker and target for cancer therapy.
蛋白酪氨酸磷酸酶非受体型 11（PTPN11）是一种多功能的酪氨酸磷酸酶，在多种类型的肿瘤中都具有重要作用。迄今为止，PTPN11 的表达谱及其在泛癌诊断中的意义尚不清楚。本研究借助 The Cancer Genome Atlas（TCGA）和 Gene Expression Omnibus（GEO）数据库，全面绘制了 33 种人类肿瘤中 PTPN11 的表达谱、预后意义、遗传改变、磷酸化状态、免疫细胞浸润和功能特性。在不同肿瘤中， 表达水平不一致，并且 表达的改变预测了癌症患者的生存结局。 表达的遗传改变水平与某些肿瘤预测之间存在显著关联。此外，在乳腺癌、透明细胞肾细胞癌、头颈部癌和肺腺癌（LUAD）中观察到 PTPN11 磷酸化水平降低。此外， 表达与癌症相关成纤维细胞和内皮细胞的浸润以及肿瘤突变负荷、微卫星不稳定性、错配修复基因和免疫调节剂密切相关。最后，通路富集分析表明，PTPN11 相关术语和通路与恶性肿瘤有关。综上所述，PTPN11 可能成为癌症治疗的新生物标志物和靶点。
