高剂量利福平治疗大鼠肝实质细胞的超微结构变化
Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin.
作者信息
Piriou A, Maissiat R, Jacqueson A, Warnet J M, Claude J R
出版信息
Br J Exp Pathol. 1987 Apr;68(2):201-7.
Abstract
Ultrastructural study of hepatic parenchyma was carried out in female Wistar rats after they had received high doses (400 mg X kg-1) of rifampicin for 1, 2, 4, 6 and 8 days. Morphological changes in the endoplasmic reticulum, Golgi apparatus and mitochondria were observed as early as day 1 of intoxication. These changes corroborate the biochemical data available regarding RFP-induced fatty liver.
摘要
在雌性Wistar大鼠接受高剂量（400mg×kg⁻¹）利福平1、2、4、6和8天后，对其肝实质进行了超微结构研究。早在中毒第1天就观察到内质网、高尔基体和线粒体的形态学变化。这些变化证实了关于利福平诱导脂肪肝的现有生化数据。
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