细胞竞争与早期哺乳动物发育的调节性质。

Cell competition and the regulative nature of early mammalian development.

机构信息

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK.

National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

出版信息

Cell Stem Cell. 2022 Jul 7;29(7):1018-1030. doi: 10.1016/j.stem.2022.06.003.

DOI:10.1016/j.stem.2022.06.003

PMID:35803224

Abstract

The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the presence of aberrant cells, adjust its growth so that its size is in accordance with its developmental stage, or integrate cells of another species to form fully functional organs. Here, we will discuss the contribution that cell competition, a quality control that eliminates viable cells that are less fit than their neighbors, makes to this plasticity. We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and how they contribute to ensure normal development of the embryo.

摘要

哺乳动物胚胎表现出惊人的可塑性，使其能够纠正异常细胞的存在，调整其生长速度，使其大小与发育阶段相适应，或者整合另一种物种的细胞形成具有完全功能的器官。在这里，我们将讨论细胞竞争在这种可塑性中的作用，细胞竞争是一种质量控制，可消除比其邻居适应性差的存活细胞。我们将通过回顾细胞竞争在早期哺乳动物胚胎中的作用以及它们如何有助于确保胚胎正常发育来实现这一目标。