哺乳动物胚胎的自我组织原理。
Principles of Self-Organization of the Mammalian Embryo.
机构信息
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK; Present address: Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK; Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.
出版信息
Cell. 2020 Dec 10;183(6):1467-1478. doi: 10.1016/j.cell.2020.11.003.
Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation. The underlying mechanisms enabling such regulative development have long been a topic of study. In this Review, we summarize our current understanding of the self-organizing principles behind the regulative nature of the early mammalian embryo. We argue that geometrical constraints, feedback between mechanical and biochemical factors, and cellular heterogeneity are all required to ensure the developmental plasticity of mammalian embryo development.
早期胚胎发生是一个保守的、自我组织的过程。在哺乳动物胚胎中，自我组织的潜力表现在其非凡的发育可塑性上，即使受到实验干扰，也能产生正确模式的胚胎。长期以来，支持这种调节发育的潜在机制一直是研究的主题。在这篇综述中，我们总结了我们目前对调节性早期哺乳动物胚胎背后的自我组织原则的理解。我们认为，几何约束、机械和生化因素之间的反馈以及细胞异质性都是确保哺乳动物胚胎发育的发育可塑性所必需的。
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