Wright A, Steele P, Bennett J R, Watts G, Polak A
Br J Obstet Gynaecol. 1987 May;94(5):408-12. doi: 10.1111/j.1471-0528.1987.tb03117.x.
The urinary excretion of albumin was measured in a group of normal pregnant women at 14, 28 and 36 weeks gestation and 6 weeks postpartum. Using 2-h urine collections, the excretion rate was not found to increase during pregnancy or to differ from that in a group of non-pregnant controls. The urinary albumin to creatinine concentration ratio was greater at all stages of pregnancy than in the non-pregnant controls and greater at 36 weeks than at 14 weeks gestation. Correcting for the observed changes in serum albumin and creatinine clearance produced evidence consistent with the hypothesis that mean glomerular permeability to albumin rises progressively during pregnancy. Reasons are given why the measurement of urinary albumin excretion may be a useful screening test in some pregnant women, and may also yield useful information on the effect of multiple pregnancies on renal function. One grand multipara was studied and found to have an increased excretion of albumin at each stage of pregnancy.
对一组正常孕妇在妊娠14周、28周、36周以及产后6周时的尿白蛋白排泄情况进行了测量。通过收集2小时尿液，发现排泄率在孕期并未增加，且与一组非孕对照组并无差异。妊娠各阶段的尿白蛋白与肌酐浓度比值均高于非孕对照组，且在妊娠36周时高于妊娠14周时。对观察到的血清白蛋白和肌酐清除率变化进行校正后，得出的证据与以下假设一致：即孕期肾小球对白蛋白的平均通透性会逐渐升高。文中给出了理由，说明为何尿白蛋白排泄量的测量可能是某些孕妇有用的筛查试验，并且还可能提供关于多胎妊娠对肾功能影响的有用信息。对一名经产妇进行了研究，发现其在妊娠各阶段的白蛋白排泄量均增加。
