Douma C E, van der Post J A, van Acker B A, Boer K, Koopman M G
Department of Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
Br J Obstet Gynaecol. 1995 Feb;102(2):107-10. doi: 10.1111/j.1471-0528.1995.tb09061.x.
The hypothesis was tested that circadian variations in urinary albumin excretion of pregnant women in the third trimester of normal pregnancy are different from nonpregnant individuals.
Circadian variability in urinary albumin excretion was studied both in pregnant women and in nonpregnant controls either during normal daily activities or in contrast during continuous bedrest with standardised fluid and food intake to study endogenously generated rhythm.
Outpatient department and metabolic ward of a university hospital.
Urinary albumin excretion during fixed time periods over the day and the night.
Both ambulant pregnant and nonpregnant women have circadian rhythm in urinary albumin excretion but pregnant women have, firstly, a higher 24 h urinary albumin excretion, secondly, smaller relative day-night differences than nonpregnant controls and thirdly, in the metabolic ward some pregnant women demonstrate absence of rhythm.
The higher albumin excretion during pregnancy in 24 h urine collections can largely be explained by a higher excretion during the night, compared with that of nonpregnant women. The day-night difference in urinary albumin excretion of ambulant pregnant women is exogenously determined.
检验如下假设：正常妊娠晚期孕妇尿白蛋白排泄的昼夜变化与非孕妇不同。
在孕妇和非孕妇对照组中，研究尿白蛋白排泄的昼夜变异性，研究在正常日常活动期间进行，或者在标准化液体和食物摄入的持续卧床休息期间进行，以研究内源性节律。
大学医院门诊部和代谢病房。
白天和夜间固定时间段的尿白蛋白排泄情况。
活动状态下的孕妇和非孕妇尿白蛋白排泄均有昼夜节律，但孕妇首先24小时尿白蛋白排泄量更高，其次与非孕妇对照组相比昼夜相对差异更小，第三，在代谢病房一些孕妇表现出节律缺失。
与非孕妇相比，妊娠期间24小时尿液收集的白蛋白排泄量较高，很大程度上可以用夜间排泄量较高来解释。活动状态下孕妇尿白蛋白排泄的昼夜差异是由外源性因素决定的。
