Department of Biological Sciences, Department of Chemistry, Herbert Irving Comprehensive Cancer Center, Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.
Cell. 2022 Jul 7;185(14):2401-2421. doi: 10.1016/j.cell.2022.06.003.
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unanswered questions in the ferroptosis field are highlighted. The next decade promises to yield further breakthroughs in the mechanisms governing ferroptosis and additional ways of harnessing ferroptosis for therapeutic benefit.
铁死亡，一种由铁依赖性脂质过氧化驱动的细胞死亡形式，在十年前被确定为一种独特的现象，并被命名为铁死亡。铁死亡已经在从发育到衰老、免疫和癌症等广泛的生物学背景中被牵涉到。这篇综述描述了在代谢、ROS 生物学和铁生物学框架内这种细胞死亡形式的关键调节剂。突出了铁死亡领域的关键概念和尚未解决的主要问题。未来十年有望在铁死亡的调控机制方面取得进一步的突破，并为治疗益处提供更多利用铁死亡的方法。
