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腹主动脉瘤腔内修复术在临床表现和治疗结果方面的种族差异。

Racial disparities in presentation and outcomes for endovascular abdominal aortic aneurysm repair.

作者信息

Ribieras Antoine J, Kang Naixin, Shao Tony, Kenel-Pierre Stefan, Rey Jorge, Velazquez Omaida C, Bornak Arash

机构信息

Division of Vascular and Endovascular Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL.

Division of Vascular and Endovascular Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL.

出版信息

J Vasc Surg. 2023 Jan;77(1):69-77. doi: 10.1016/j.jvs.2022.06.094. Epub 2022 Jul 6.

Abstract

OBJECTIVE

In the present study, we used a national database to identify racial differences in the presentation and outcomes for patients undergoing endovascular abdominal aortic aneurysm (AAA) repair (EVAR) and identified areas for improving their care.

METHODS

We queried the EVAR-targeted National Surgical Quality Improvement Program database (2016-2019) to identify patients who had undergone EVAR for both ruptured and nonruptured AAAs. The patients were categorized according to race (White, Black, and Asian). Patients with a history of abdominal aortic surgery or an indication other than AAAs were excluded. The data was analyzed using the χ and Kruskal-Wallis tests, presented as frequencies and percentages or median and interquartile range (IQR) for categorical and continuous variables, respectively.

RESULTS

We identified 3629 patients (16.6% female), including 3312 White (91.3%), 248 Black (6.8%), and 69 Asian (1.9%) patients. Black patients were more frequently women (27.0%) compared with White patients (15.9%) and were younger (median age, 71 years; IQR, 64-77 years) than White (median age, 73 years; IQR, 67-79 years) and Asian (median age, 76 years; IQR, 67-81 years) patients (P < .001 for both). The incidence of smoking, congestive heart failure, and dialysis dependency was highest for Black patients, and the incidence of obesity was lowest for Asian patients. The AAAs in Black patients extended more frequently beyond the aortic bifurcation (P = .047). In Asian patients, the internal iliac arteries were more involved (P = .040). For Black patients, 29.8% of the EVARs were performed in a nonelective setting compared with 20.2% for the White and 15.9% for the Asian patients (P < .001). The aneurysm diameter, nonruptured symptomatic rate, and rupture rate were similar across the groups (P = .807). The operative time was prolonged for Black (median, 128 minutes; IQR, 96-177 minutes) compared with White (median, 114 minutes; IQR, 84-162 minutes) patients (P < .001). Postoperatively, Black patients were more likely to require blood transfusion (16.5%) and had prolonged length of hospital stay (median, 2 days; IQR, 1-4 days) compared with White (10.0%; median, 1 day; IQR, 1-3 days) and Asian (4.3%; median, 1 day; IQR, 1-3 days) patients (P = .001 and P < .001, respectively). Black patients also had a higher 30-day readmission rate (P = .038). On multivariate analysis, Black race was an independent factor for length of stay >1 day after both elective and nonelective EVAR and 30-day readmission for elective EVAR, but not 30-day mortality after elective and nonelective EVAR.

CONCLUSIONS

In the present nationwide sample of EVAR cases, Black patients were more often women and younger. Despite similar rates of symptomatic and ruptured AAAs at presentation and 30-day mortality, Black patients more often presented and were treated during the same nonelective admission; they also had associated increased length of hospital stay and readmission. These findings signal a missed opportunity to diagnose, optimize, and treat this particular group of patients in an elective setting.

摘要

目的

在本研究中,我们使用国家数据库来确定接受血管内腹主动脉瘤(AAA)修复术(EVAR)的患者在临床表现和治疗结果方面的种族差异,并确定改善其治疗的领域。

方法

我们查询了以EVAR为目标的国家外科质量改进计划数据库(2016 - 2019年),以确定接受过破裂和未破裂AAA的EVAR治疗的患者。患者按种族(白人、黑人、亚洲人)分类。排除有腹主动脉手术史或AAA以外适应症的患者。数据分别使用χ检验和Kruskal - Wallis检验进行分析,分类变量和连续变量分别以频率和百分比或中位数和四分位间距(IQR)表示。

结果

我们确定了3629例患者(16.6%为女性),包括3312例白人(91.3%)、248例黑人(6.8%)和69例亚洲人(1.9%)患者。与白人患者(15.9%)相比,黑人患者中女性比例更高(27.0%),且比白人(中位年龄73岁;IQR,67 - 79岁)和亚洲人(中位年龄76岁;IQR,67 - 81岁)患者更年轻(中位年龄71岁;IQR,64 - 77岁)(两者P均<0.001)。黑人患者吸烟、充血性心力衰竭和透析依赖的发生率最高,亚洲患者肥胖的发生率最低。黑人患者的AAA更常延伸至主动脉分叉以下(P = 0.047)。在亚洲患者中,髂内动脉受累更多(P = 0.040)。对于黑人患者,29.8%的EVAR手术是在非择期情况下进行的,而白人患者为20.2%,亚洲患者为15.9%(P < 0.001)。各组间动脉瘤直径、未破裂症状发生率和破裂率相似(P = 0.807)。与白人患者(中位时间114分钟;IQR,84 - 162分钟)相比,黑人患者的手术时间延长(中位时间128分钟;IQR,96 - 177分钟)(P < 0.001)。术后,与白人(10.0%;中位时间1天;IQR,1 - 3天)和亚洲人(4.3%;中位时间1天;IQR,1 - 3天)患者相比,黑人患者更有可能需要输血(16.5%),住院时间延长(中位时间2天;IQR,1 - 4天)(分别为P = 0.001和P < 0.001)。黑人患者的30天再入院率也更高(P = 0.038)。多因素分析显示,黑人种族是择期和非择期EVAR术后住院时间>1天以及择期EVAR术后30天再入院的独立因素,但不是择期和非择期EVAR术后30天死亡率的独立因素。

结论

在目前全国范围内的EVAR病例样本中,黑人患者女性更多且更年轻。尽管在就诊时症状性和破裂性AAA的发生率以及30天死亡率相似,但黑人患者更常在同一非择期入院时就诊和接受治疗;他们还伴有住院时间延长和再入院率增加。这些发现表明在择期情况下诊断、优化和治疗这一特定患者群体方面存在错失的机会。

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