2 型糖尿病对乳腺癌女性死亡率的影响：一项匹配病例对照研究。

Influence of type 2 diabetes mellitus on mortality in women with breast cancer: A matched case-control study.

作者信息

de Los A Jiménez Prieto Perla, Alvarez Bañuelos María T, Romero Jaime Morales, Córdoba Betzaida Cuevas, Sampieri Clara L, Cuevas Roberto Zenteno, Guzmán García Raúl E

机构信息

Universidad Veracruzana, Instituto de Salud Pública, Xalapa Veracruz 91190, Mexico.

出版信息

J Diabetes Complications. 2022 Aug;36(8):108249. doi: 10.1016/j.jdiacomp.2022.108249. Epub 2022 Jun 28.

DOI:10.1016/j.jdiacomp.2022.108249

PMID:35803840

Abstract

AIMS

The study assessed the association between the presence of type2 diabetes mellitus (T2DM) and mortality in women with breast cancer (BC).

METHODS

A matched pair case-control study was conducted at the State Cancer Center, which is located in Xalapa, Veracruz, Mexico. It was matched by age (±3 years) within a cohort of 1442 patients with BC. Descriptive statistics were performed. Analysis through paired odds ratio (OR and multivariate analyses were used to calculate the association between BC mortality and the variables studied.

RESULTS

166 cases and 166 controls with confirmed diagnosis of BC were studied, with a mean age of 52.9 ± 11.9 years. The T2DM was associated with an increased mortality of women with BC (OR = 1.75 95 %CI 1.06-2.89). Similarly, metastasis (OR = 14.17 95 %CI 6.19-32.342), advanced clinical stage (OR = 3.04 95 %CI 1.45 - 6.38), and the molecular subtypes Her2 (OR = 2.0 95 %CI 1.02-3.92), and triple negative (OR = 3.54 95 %CI 1.72-7.32). There was no difference in mean glucose between cases and controls (208.9 ± 132 vs 194.4 ± 90.4 mg/dL, respectively).

CONCLUSION

T2DM was found to be a relevant risk factor for BC mortality in this Mexican population. Thus, it is important to consider the presence and evolution of DM in the prevention programs, diagnostic algorithms and treatments established for BC.

摘要

目的

本研究旨在评估 2 型糖尿病（T2DM）与乳腺癌（BC）女性患者死亡率之间的关系。

方法

本研究采用病例对照配对设计，在位于墨西哥韦拉克鲁斯州哈拉帕的州癌症中心进行。该研究纳入了 1442 例 BC 患者队列，按照年龄（±3 岁）进行配对。进行描述性统计分析。通过配对比值比（OR）和多变量分析，计算 BC 死亡率与研究变量之间的关联。

结果

研究纳入了 166 例确诊为 BC 的病例和 166 例对照，平均年龄为 52.9±11.9 岁。T2DM 与 BC 女性患者死亡率升高相关（OR=1.75，95%CI 1.06-2.89）。同样，转移（OR=14.17，95%CI 6.19-32.342）、晚期临床分期（OR=3.04，95%CI 1.45-6.38）以及 Her2 分子亚型（OR=2.0，95%CI 1.02-3.92）和三阴性（OR=3.54，95%CI 1.72-7.32）也与死亡率升高相关。病例组和对照组之间的平均血糖水平无差异（208.9±132 与 194.4±90.4mg/dL）。