Nat Med. 2022 Jul;28(7):1357-1358. doi: 10.1038/s41591-022-01892-2.
Analysis of SARS-CoV-2 evolution during chronic infection reveals that in this setting, the virus evolves to bear mutations similar to those seen in variants of concern, and that many of these mutations are associated with antibody evasion. However, as mutations associated with high SARS-CoV-2 transmissibility are not observed, the emergence of variants of concern during chronic infection might be rare.
慢性感染期间 SARS-CoV-2 进化分析表明，在这种情况下，病毒进化产生的突变与关注变异株中观察到的相似，其中许多突变与抗体逃逸有关。然而，由于未观察到与高 SARS-CoV-2 传染性相关的突变，关注变异株在慢性感染期间的出现可能较为罕见。
