Hamburger-Bar R, Kindler S, Bertish T, Lerer B
Biol Psychiatry. 1987 May;22(5):593-602. doi: 10.1016/0006-3223(87)90187-9.
Male albino rats (Sabra strain) were exposed to electroconvulsive shock (ECS) once daily for periods ranging from 1 to 13 days, and proactive effects on conditioned avoidance response (CAR) acquisition and extinction were studied. CAR acquisition was intact following both single and repeated ECS, but extinction was accelerated by multiple ECS administration. These findings resembled the effect of repeated ECS on anterograde memory function in humans and confirmed previous observations based on a passive avoidance paradigm. However, extinction was not accelerated in a different rat strain (LC2). Parallel open field activity measures suggested that these findings were not related to ECS-induced alterations in locomotor activity. Administration of arginine vasopressin prior to each ECS, or following acquisition sessions, as well as 1-desamino-8-D-arginine vasopressin administration following acquisition sessions, did not ameliorate ECS-induced deficits in the Sabra rats. Differences between the present paradigm of ECS administration and those in which positive effects of vasopressin and other neuropeptides have been reported are discussed. The potential research applications of a rodent model of ECS-induced memory impairment that parallels deficits encountered in the clinical context are considered.
雄性白化大鼠（Sabra品系）每天接受一次电惊厥休克（ECS），持续时间从1天到13天不等，并研究其对条件性回避反应（CAR）获得和消退的前瞻性影响。单次和重复ECS后，CAR获得均未受影响，但多次给予ECS会加速消退。这些发现类似于重复ECS对人类顺行性记忆功能的影响，并证实了基于被动回避范式的先前观察结果。然而，在另一种大鼠品系（LC2）中，消退并未加速。平行的旷场活动测量表明，这些发现与ECS诱导的运动活动改变无关。在每次ECS之前、获得训练后给予精氨酸加压素，以及在获得训练后给予1-去氨基-8-D-精氨酸加压素，均未改善Sabra大鼠中ECS诱导的缺陷。讨论了本ECS给药范式与已报道加压素和其他神经肽具有积极作用的范式之间的差异。考虑了与临床背景中遇到的缺陷相似的ECS诱导记忆损伤啮齿动物模型的潜在研究应用。
