Szórády I, Sánta A, Veress I
Biol Res Pregnancy Perinatol. 1987;8(1 1ST Half):23-5.
The distribution of drug acetylator phenotypes in 100 healthy newborn infants was studied and compared with the acetylator phenotypes frequency in different age groups. Phenotyping was performed by assaying total and free sulphadimidine in the urine after single oral test dose of the drug/100 mg. As in elderly subjects, slow acetylator phenotype was predominant also in healthy newborns (83%), which was the highest frequency of all age groups observed. Acetylator phenotype in the newborn infants may be influenced by genetic, environmental (e.g., nutritive), as well as by developmental factors (e.g., postnatal enzyme deficiency, age-specific changes in organ functions, etc.). In this connection, slow acetylator phenotype of the neonate may be related to a negative pantothenic acid balance causing insufficient Coenzyme-A synthesis, too. The predominance of the slow acetylator phenotype resulting in higher drug sensitivity can be regarded clinically as a special risk factor in human neonates.
研究了100名健康新生儿中药物乙酰化酶表型的分布情况，并与不同年龄组的乙酰化酶表型频率进行了比较。通过单次口服100毫克药物的试验剂量后检测尿液中总磺胺二甲嘧啶和游离磺胺二甲嘧啶来进行表型分析。与老年受试者一样，健康新生儿中慢乙酰化酶表型也占主导（83%），这是所有观察到的年龄组中频率最高的。新生儿的乙酰化酶表型可能受遗传、环境（如营养）以及发育因素（如出生后酶缺乏、器官功能的年龄特异性变化等）的影响。就此而言，新生儿的慢乙酰化酶表型也可能与泛酸负平衡导致辅酶A合成不足有关。慢乙酰化酶表型占主导导致更高的药物敏感性，在临床上可被视为人类新生儿的一个特殊风险因素。
