Cunningham Lily, Zhou Huitong, Fang Qian, Tapley Mark, Hickford Jonathan G H
Department of Agricultural Sciences, Lincoln University, Lincoln 7647, New Zealand.
Peel Forest Estate, Peel Forest, Geraldine 7992, New Zealand.
Animals (Basel). 2022 Jun 23;12(13):1615. doi: 10.3390/ani12131615.
Myostatin (MSTN), also known as growth differentiation factor 8 (GDF-8), is a negative regulator of lean muscle tissue growth. Variation in the gene has been studied in many domesticated species, because of its potential to dramatically increase muscle mass. It has, however, not been investigated in red deer (). In this study, variation in intron 1 was investigated in 211 male New Zealand red deer, for which phenotypic measurements of (eye muscle) (width, depth, and area, together with 12-month weight) were recorded. Two sequence variants (named and ) differing by one nucleotide (c.373 + 224) were identified in the intron 1 region of the gene resulting in three genotypes (, and ; frequencies of 63.5%, 30.8%, and 5.7%, respectively), but no association between this variation and any of the quantitative measurements was detected. These results suggest that the deer is less variable than for other livestock species and that its activity may be controlled to maintain a size-growth equilibrium.
肌肉生长抑制素（MSTN），也被称为生长分化因子8（GDF - 8），是瘦肉组织生长的负调节因子。由于该基因变异有显著增加肌肉量的潜力，因此已在许多家养物种中进行了研究。然而，尚未在马鹿中进行调查。在本研究中，对211头雄性新西兰马鹿的内含子1变异进行了调查，并记录了其（眼肌）（宽度、深度和面积以及12个月龄体重）的表型测量值。在该基因的内含子1区域鉴定出两个相差一个核苷酸（c.373 + 224）的序列变异体（命名为 和 ），产生了三种基因型（ 、 和 ；频率分别为63.5%、30.8%和5.7%），但未检测到这种变异与任何定量测量值之间的关联。这些结果表明，马鹿的变异性低于其他家畜物种，并且其活性可能受到控制以维持体型 - 生长平衡。
