Balázs Katalin, Kocsis Zsuzsa S, Ágoston Péter, Jorgo Kliton, Gesztesi László, Farkas Gyöngyi, Székely Gábor, Takácsi-Nagy Zoltán, Polgár Csaba, Sáfrány Géza, Jurányi Zsolt, Lumniczky Katalin
National Public Health Center, Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, 1221 Budapest, Hungary.
Doctoral School of Pathological Sciences, Semmelweis University, 1085 Budapest, Hungary.
Cancers (Basel). 2022 Jun 22;14(13):3058. doi: 10.3390/cancers14133058.
The development of cancer and anti-tumor therapies can lead to systemic immune alterations but little is known about how long immune dysfunction persists in cancer survivors.
We followed changes in the cellular immune parameters of prostate cancer patients with good prognostic criteria treated with low dose rate brachytherapy before and up to 3 years after the initiation of therapy.
Patients before therapy had a reduced CD4+ T cell pool and increased regulatory T cell fraction and these alterations persisted or got amplified during the 36-month follow-up. A significant decrease in the total NK cell number and a redistribution of the circulating NK cells in favor of a less functional anergic subpopulation was seen in patients before therapy but tumor regression led to the regeneration of the NK cell pool and functional integrity. The fraction of lymphoid DCs was increased in patients both before therapy and throughout the whole follow-up. Increased PDGF-AA, BB, CCL5 and CXCL5 levels were measured in patients before treatment but protein levels rapidly normalized.
while NK cell dysfunction recovered, long-term, residual alterations persisted in the adaptive and partly in the innate immune system.
癌症的发展和抗肿瘤治疗可导致全身免疫改变，但对于癌症幸存者免疫功能障碍持续多长时间知之甚少。
我们跟踪了符合良好预后标准的前列腺癌患者在低剂量率近距离放射治疗开始前及治疗后长达3年的细胞免疫参数变化。
治疗前患者的CD4+T细胞池减少，调节性T细胞比例增加，这些改变在36个月的随访期间持续存在或加剧。治疗前患者的总自然杀伤（NK）细胞数量显著减少，循环NK细胞重新分布，有利于功能较弱的无反应亚群，但肿瘤消退导致NK细胞池再生和功能完整性恢复。治疗前及整个随访期间患者的淋巴树突状细胞比例均增加。治疗前患者的血小板衍生生长因子（PDGF）-AA、BB、趋化因子配体5（CCL5）和趋化因子CXCL5水平升高，但蛋白水平迅速恢复正常。
虽然NK细胞功能障碍得以恢复，但适应性免疫系统及部分先天性免疫系统中长期残留的改变依然存在。
