Department of Veterinary Medicine, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan.
Department of Medical Imaging, Chung Shan Medical University Hospital, 110 Jianguo North Road, Taichung 40201, Taiwan.
Int J Environ Res Public Health. 2022 Jun 22;19(13):7651. doi: 10.3390/ijerph19137651.
This study aimed to evaluate the risk of cataract formation associated with radiation exposure from 18F-FDG PET/CT in oncology patients, using data from Taiwan's National Health Insurance Research Database. The exposed group (Group E) consisted of oncology patients receiving 18F-FDG PET/CT within the first year of a cancer diagnosis. The comparison group (Group C) included subjects who had never been exposed to 18F-FDG PET/CT radiation and were propensity score-matched by date of enrolment, age, sex, cancer type, associated comorbidities, and CT utilization. Multiple Cox proportional hazard regression analysis was used to estimate the hazard ratio (HR) of cataract risk due to radiation exposure, while adjusting for potential confounding factors. A total of 703 patients and 1406 matched subjects were in Groups E and C, respectively. The incidence of cataract formation was not significantly higher among subjects in Group E (adjusted HR = 1.264; 95% confidence interval [CI] = 0.845-1.891). Our results revealed that 18F-FDG PET/CT was not a significant risk factor for developing cataracts in oncology patients.
本研究旨在利用台湾全民健康保险研究数据库的数据，评估肿瘤患者接受 18F-FDG PET/CT 辐射相关白内障形成的风险。暴露组（E 组）包括在癌症诊断后一年内接受 18F-FDG PET/CT 的肿瘤患者。对照组（C 组）包括从未接受过 18F-FDG PET/CT 辐射且通过登记日期、年龄、性别、癌症类型、相关合并症和 CT 使用情况进行倾向评分匹配的受试者。使用多 Cox 比例风险回归分析估计因辐射暴露导致白内障风险的风险比（HR），同时调整潜在混杂因素。E 组和 C 组分别有 703 例和 1406 例匹配的受试者。E 组中白内障形成的发生率并没有显著升高（调整后的 HR = 1.264；95%置信区间 [CI] = 0.845-1.891）。我们的结果表明，18F-FDG PET/CT 不是肿瘤患者发生白内障的显著危险因素。
