Department of Mental Health, Mutua Terrassa University Hospital, 5 Dr Robert Square, 08221 Terrassa, Spain.
University of Barcelona, CIBERSAM, 08221 Terrassa, Spain.
Int J Environ Res Public Health. 2022 Jun 28;19(13):7911. doi: 10.3390/ijerph19137911.
The theme, strength, and duration of a delusion are considered important in distinguishing one psychosis of old age from another. Research results, however, are mostly based on studies conducted on one form of psychosis, namely schizophrenia. The aim of this hypothesis-driven narrative review is to gather clinically important information about the psychosis identified as delusional disorder (DD), as it affects persons of senior age. We hypothesized that DD becomes relatively prevalent in old age, especially in women; and that it is associated with demonstrable brain changes, which, in turn, are associated with cognitive defects and poor pharmacological response, thus increasing the risk of aggression and suicide. Computerized searches in PubMed and ClinicalTrials.gov were conducted using the following search terms: (delusional disorder) AND (elderly OR old OR aged OR psychogeriatrics). A total of 16 recent studies (including case reports) were reviewed. Our hypotheses could not be definitively confirmed because research evidence is lacking. In order to improve eventual outcomes, our literature search demonstrates the need for more targeted, well-designed studies.
妄想的主题、强度和持续时间被认为是区分老年期精神分裂症与其他精神疾病的重要因素。然而，研究结果主要基于对一种精神疾病（即精神分裂症）的研究。本假设驱动的叙述性综述旨在收集与被确定为妄想障碍（DD）的精神疾病相关的重要临床信息，因为它会影响到老年人群。我们假设，DD 在老年时相对普遍，尤其是在女性中；并且与可证明的大脑变化有关，而这些变化又与认知缺陷和药物反应不良有关，从而增加了攻击和自杀的风险。在 PubMed 和 ClinicalTrials.gov 中使用以下搜索词进行了计算机检索：（妄想障碍）和（老年人或老年或年龄或老年精神病学）。共综述了 16 项近期研究（包括病例报告）。由于缺乏研究证据，我们的假设无法得到明确证实。为了改善最终结果，我们的文献检索表明需要更有针对性、设计更好的研究。
