Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
Int J Environ Res Public Health. 2022 Jun 29;19(13):7954. doi: 10.3390/ijerph19137954.
Acute respiratory illness caused by exposure to welding-associated zinc oxide fumes is known as metal fume fever (MFF). MFF is generally characterized as a self-limiting disease. Few studies have reported chemical pneumonitis associated with zinc fume inhalation. We report a case study involving severe episodes of MFF accompanied by chemical pneumonitis due to the inhalation of zinc oxide fumes while operating an arc welder. A 54-year-old man developed flu-like symptoms after arc welding galvanized steel in a poorly ventilated area. Despite intravenous antibiotics therapy, his clinical course worsened, and his urine zinc concentration was remarkably elevated (3579 μg/24 h; reference range, 0-616 μg/24 h). A chest computed tomography revealed extensive consolidation, ground-glass opacity in the lungs, and right pleural effusion. After corticosteroid treatment, the patient's symptoms and radiologic findings significantly improved. It should be noted that the inhalation of zinc oxide fumes can occasionally induce acute lung injury via inflammatory responses and oxidative stress.
由于接触焊接相关的氧化锌烟尘而引起的急性呼吸道疾病被称为金属烟雾热（MFF）。MFF 通常表现为自限性疾病。很少有研究报告与吸入锌烟尘有关的化学性肺炎。我们报告了一例因在通风不良的区域使用电弧焊机焊接镀锌钢而吸入氧化锌烟尘，同时伴有严重的 MFF 发作和化学性肺炎的病例研究。一名 54 岁男性在电弧焊接镀锌钢后出现流感样症状。尽管静脉内使用抗生素治疗，但他的临床病程恶化，尿锌浓度明显升高（3579μg/24 h；参考范围，0-616μg/24 h）。胸部计算机断层扫描显示肺部广泛实变、磨玻璃影和右侧胸腔积液。皮质类固醇治疗后，患者的症状和影像学发现明显改善。需要注意的是，吸入氧化锌烟尘偶尔会通过炎症反应和氧化应激引起急性肺损伤。
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