Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Faculty of Medicine and Cancerology State Institute, University of Colima, Colima State Health Services, Colima 28040, CP, Mexico.
Int J Environ Res Public Health. 2022 Jul 2;19(13):8142. doi: 10.3390/ijerph19138142.
Thyroid hormone abnormalities are among the most common endocrine disorders comorbidly suffered alongside metabolic syndrome and type 2 diabetes mellitus (T2DM), and within the euthyroid range they may also impact other outcomes, such as mood disorders. This study aimed to observationally examine the relationship between TSH and social determinants of health and clinical measures in a euthyroid Hispanic/Latinx patient sample with a diagnosis of anxiety and/or depression disorders from a community health clinic. A needs assessment was completed using a random sample of 100 de-identified medical records of individuals who received free medical care, including mental health, at a community-based clinic. Those with low normal TSH (<2 mIU/L) compared with high normal TSH (≥2 mIU/L) had a greater odds of food insecurity (p = 0.016) and being at 100% of the federal poverty level (p = 0.015). The low normal TSH group had significantly higher fasting glucose (p = 0.046), hemoglobin A1c (p = 0.018), and total cholesterol (p = 0.034) compared with the high normal TSH group. In those with T2DM, individuals with low normal TSH had six-times greater odds of having high fasting glucose (p = 0.022) and high hemoglobin A1c (p = 0.029). These relationships warrant further study, to inform future public health policies and follow-up care for underserved and vulnerable communities.
甲状腺激素异常是与代谢综合征和 2 型糖尿病（T2DM）并存的最常见内分泌紊乱之一，在甲状腺功能正常范围内，它们也可能影响其他结果，如情绪障碍。本研究旨在观察性研究甲状腺刺激素（TSH）与健康社会决定因素和临床指标在甲状腺功能正常的西班牙裔/拉丁裔患者样本中的关系，这些患者来自社区健康诊所，被诊断为焦虑和/或抑郁障碍。使用从社区诊所获得免费医疗保健（包括心理健康）的 100 份匿名医疗记录的随机样本完成需求评估。与高正常 TSH（≥2 mIU/L）相比，低正常 TSH（<2 mIU/L）的个体更有可能出现食物不安全（p = 0.016）和处于联邦贫困线的 100%（p = 0.015）。与高正常 TSH 组相比，低正常 TSH 组的空腹血糖（p = 0.046）、血红蛋白 A1c（p = 0.018）和总胆固醇（p = 0.034）显著更高。在患有 T2DM 的个体中，低正常 TSH 的个体空腹血糖升高（p = 0.022）和血红蛋白 A1c 升高（p = 0.029）的几率高 6 倍。这些关系值得进一步研究，为未来为服务不足和弱势群体的公共卫生政策和后续护理提供信息。
