Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia.
Int J Mol Sci. 2022 Jun 22;23(13):6926. doi: 10.3390/ijms23136926.
Aging is one of the most intriguing processes of human ontogenesis. It is associated with the development of a wide variety of diseases affecting all organs and their systems. The victory over aging is the most desired goal of scientists; however, it is hardly achievable in the foreseeable future due to the complexity and ambiguity of the process itself. All body systems age, lose their performance, and structural disorders accumulate. The cardiovascular system is no exception. And it is cardiovascular diseases that occupy a leading position as a cause of death, especially among the elderly. The aging of the cardiovascular system is well described from a mechanical point of view. Moreover, it is known that at the cellular level, a huge number of mechanisms are involved in this process, from mitochondrial dysfunction to inflammation. It is on these mechanisms, as well as the potential for taking control of the aging of the cardiovascular system, that we focused on in this review.
衰老是人类个体发生中最有趣的过程之一。它与各种影响所有器官及其系统的疾病的发展有关。战胜衰老，是科学家最渴望实现的目标；然而，由于这一过程本身的复杂性和模糊性，在可预见的未来，这一目标很难实现。所有的身体系统都会衰老，失去功能，结构紊乱也会积累。心血管系统也不例外。心血管疾病尤其在老年人中，占据着死亡原因的首要位置。从机械的角度来看，心血管系统的衰老已经得到了很好的描述。此外，众所周知，在细胞水平上，有大量的机制参与了这个过程，从线粒体功能障碍到炎症。我们在这篇综述中关注的就是这些机制，以及控制心血管系统衰老的潜力。
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