Center for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, China.
Int J Mol Sci. 2022 Jun 26;23(13):7105. doi: 10.3390/ijms23137105.
Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including Na, K, Ca, and TRP families, are the major targets of peptide neurotoxins. Insight into the mechanism of neurotoxins acting on ion channels contributes to our understanding of the function of both channels and centipede venoms. Meanwhile, the novel structure and selective activities give them the enormous potential to be modified and exploited as research tools and biological drugs. Here, we review the centipede venom peptides that act on ion channels.
蜈蚣是最古老和最成功的有毒动物之一。它们进化出了可怕的毒液来威慑捕食者或猎食猎物，并且除了南极洲以外，广泛分布于世界各地。神经毒素是影响神经系统功能的最重要的毒力因子。在神经系统中表达的离子通道和受体，包括 Na、K、Ca 和 TRP 家族，是肽神经毒素的主要靶标。深入了解神经毒素作用于离子通道的机制有助于我们理解通道和蜈蚣毒液的功能。同时，其新颖的结构和选择性活性使它们具有巨大的潜力，可以作为研究工具和生物药物进行修饰和利用。在这里，我们综述了作用于离子通道的蜈蚣毒液肽。
