College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Dalton Trans. 2020 Feb 21;49(7):2209-2217. doi: 10.1039/c9dt04867g. Epub 2020 Jan 31.
Photothermal therapy (PTT) is a promising treatment for tumors due to its efficiency and non-invasiveness. However, during the PTT treatment, reactive oxygen species (ROS) are produced in response to hyperthermia and thus harm the neighboring normal cells. In this work, a multifunctional theranostic agent (Se@SiO@Au-PEG/DOX NCs) was exploited to solve this problem by introducing selenium, which can efficiently prevent normal cells from oxidative damage by scavenging reactive oxygen species during photothermal therapy. In addition, the Se@SiO@Au-PEG/DOX nanocomposites (NCs) not only exhibited excellent properties of combined chemo-thermal synergistic therapy, but also showed no appreciable toxicity towards normal tissues due to the protective effect for continuous release of selenium. Thus, the fabricated Se@SiO@Au-PEG/DOX NCs provide an integrated solution to overcome the limitations of selenium and PTT, and demonstrate great prospects as a safe and highly reliable theranostic agent.
光热疗法（PTT）由于其高效性和非侵入性，是一种很有前途的肿瘤治疗方法。然而，在 PTT 治疗过程中，会产生活性氧（ROS）以响应过热，从而伤害邻近的正常细胞。在这项工作中，通过引入硒，开发了一种多功能治疗药物（Se@SiO@Au-PEG/DOX NCs），通过在光热治疗过程中清除活性氧，有效地防止正常细胞发生氧化损伤。此外，Se@SiO@Au-PEG/DOX 纳米复合材料（NCs）不仅表现出了联合化疗-热协同治疗的优异性能，而且由于硒的持续释放而具有保护作用，对正常组织也没有明显的毒性。因此，所制备的 Se@SiO@Au-PEG/DOX NCs 为克服硒和 PTT 的局限性提供了一个综合的解决方案，并展示了作为一种安全、高度可靠的治疗药物的巨大前景。
