Lin Gen-Min, Liu Pang-Yen, Tsai Kun-Zhe, Lin Yu-Kai, Huang Wei-Chun, Lavie Carl J
Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien 970, Taiwan.
Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
J Clin Med. 2022 Jun 24;11(13):3653. doi: 10.3390/jcm11133653.
Background: The relationship of cardiorespiratory fitness (CRF) with subclinical atherosclerosis affected by the body adiposity has been observed in children, whereas this relationship remains unclear in young adults. Methods and Results: A total of 1520 military recruits, aged 18−40 years, were included in Taiwan in 2018−2020. All subjects underwent detailed physical and blood laboratory examinations. CRF was evaluated by time for a 3000 m run, and subclinical atherosclerosis was evaluated by intima−media thickness of the bulb of the left common carotid artery (cIMT) utilizing high-resolution ultrasonography. Multivariable linear regression analysis with adjustments for age, sex, cigarette smoking, alcohol intake, systolic and diastolic blood pressure, high- and low-density lipoprotein cholesterols, fasting glucose, waist circumference, serum uric acid and serum triglycerides were utilized to determine the correlation between CRF and cIMT. CRF was independently correlated with cIMT (standardized β: 0.11, p < 0.001). Of the cardiometabolic risk markers, serum triglycerides were the only independent risk marker of cIMT (standardized β: 0.063, p = 0.03). In addition, the association of CRF with cIMT did not differ between those with a body mass index (BMI) ≥ 25 kg/m2 and those with BMI < 25 kg/m2 (standardized β: 0.103 and 0.117; p = 0.01 and 0.005, respectively). Conclusions: In physically active young men and women, there was an inverse association of cIMT with CRF, which was observed in both overweight/mild obesity and normal-weight individuals, highlighting the importance of endurance capacity on reducing risk of early atherosclerosis and implying that the moderation effect of body adiposity might not be present in this population.
儿童中已观察到心肺适能（CRF）与受身体肥胖影响的亚临床动脉粥样硬化之间的关系，而在年轻人中这种关系仍不明确。方法与结果：2018年至2020年期间，台湾共纳入了1520名年龄在18至40岁的新兵。所有受试者均接受了详细的体格检查和血液实验室检查。通过3000米跑步时间评估CRF，利用高分辨率超声通过左侧颈总动脉球部的内膜中层厚度（cIMT）评估亚临床动脉粥样硬化。采用多变量线性回归分析，并对年龄、性别、吸烟、饮酒、收缩压和舒张压、高密度和低密度脂蛋白胆固醇、空腹血糖、腰围、血清尿酸和血清甘油三酯进行调整，以确定CRF与cIMT之间的相关性。CRF与cIMT独立相关（标准化β：0.11，p<0.001）。在心血管代谢风险标志物中，血清甘油三酯是cIMT的唯一独立风险标志物（标准化β：0.063，p = 0.03）。此外，体重指数（BMI）≥25 kg/m²者和BMI<25 kg/m²者中，CRF与cIMT的关联无差异（标准化β：0.103和0.117；p分别为0.01和0.005）。结论：在身体活跃的年轻男性和女性中，cIMT与CRF呈负相关，在超重/轻度肥胖个体和正常体重个体中均观察到这一现象，突出了耐力能力对降低早期动脉粥样硬化风险的重要性，并暗示该人群中可能不存在身体肥胖的调节作用。
