从. 的叶子中分离得到的两个新的半日花烷二萜
Two New Seco-Labdane Diterpenoids from the Leaves of .
机构信息
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, China.
Department of Pharmacy, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China.
出版信息
Molecules. 2022 Jun 22;27(13):4018. doi: 10.3390/molecules27134018.
Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of . The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds - showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds - exhibited more potent inhibitory activity than compound . The cytotoxicity of compounds - against human hepatocellular carcinoma HepG2 cells and human gastric carcinoma SGC-7901 cells were evaluated, while all of them exhibited no cytotoxicity.
从. 的叶子中分离得到两个新的半日花烷二萜类化合物nudiflopene N（1）和nudiflopene O（2）以及四个已知化合物。通过 1D-、2D-NMR 和 HR-ESI-MS 光谱分析确定了新化合物的结构。化合物 - 对 RAW264.7 细胞中脂多糖诱导的一氧化氮（NO）产生具有抑制活性，新化合物 - 比化合物 - 表现出更强的抑制活性。评估了化合物 - 对人肝癌 HepG2 细胞和人胃癌 SGC-7901 细胞的细胞毒性，而它们均无细胞毒性。
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