一种具有抑制裸花紫珠叶一氧化氮生成活性的新型3,4-裂贝壳杉烷二萜类化合物。

A new 3,4-seco-labdane diterpenoid with inhibitory activity against the production of nitric oxide from the leaves of Callicarpa nudiflora.

作者信息

Zhang Lei, Liu Ming-Sheng, Huang Jian, Li Guo-Yu, Zhang Cui, Dong Lin, Zhang Ke, Wang Jin-Hui

机构信息

a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.

出版信息

J Asian Nat Prod Res. 2014;16(2):216-21. doi: 10.1080/10286020.2013.841675. Epub 2013 Nov 20.

DOI:10.1080/10286020.2013.841675

PMID:24251850

Abstract

A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1) exerted inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by lipopolysaccharide.

摘要

从裸花紫珠叶中分离出一种新的3,4-裂贝壳杉烷二萜，3,4-裂-12R,13S-二羟基-4(18),8(17),14(15)-贝壳杉三烯-3-酸（1）。通过一维核磁共振、二维核磁共振和高分辨电喷雾电离质谱数据阐明了1的结构，并通过单晶X射线衍射分析得到证实。3,4-裂-12R,13S-二羟基-4(18),8(17),14(15)-贝壳杉三烯-3-酸（1）对脂多糖刺激的RAW264.7细胞中一氧化氮的产生具有抑制活性。