Prashad D N, Fletcher P A, Cooper M
Br J Sports Med. 1987 Mar;21(1):9-12. doi: 10.1136/bjsm.21.1.9.
This study monitors changes in urinary excretion of water and minerals before and after exercise in pre-menopausal women and in those using oral contraception. Resting urine flow rate was lower and sodium output significantly higher (p less than 0.02) during the normal post-menstrual phase than during other phases of the cycle. These changes were unrelated to glomerular filtration rate and might impede maximal performance. After exercise an oliguria and hyponatriuresis were most pronounced during the menstrual phase. In addition the resting urinary output of calcium and magnesium were unrelated to normal oestrogenic and progestegenic cyclic surges. Amongst oral contraceptive users, resting excretion of water, minerals and creatinine were all significantly lower than general menstrual cycle values (p less than 0.01) and further reductions in salts and water output occurred with exercise. Basal calcium and magnesium excretion rates were significantly lower than general menstrual cycle values (p less than 0.05). Renal conservation of water and salts for 'pill' takers may affect renal homeostasis. The consequences of mineral retention are unknown.
本研究监测了绝经前女性及口服避孕药女性运动前后尿液中水和矿物质排泄的变化。在月经周期的正常经后期,静息尿流率较低,钠排出量显著较高(p<0.02),高于周期的其他阶段。这些变化与肾小球滤过率无关,可能会妨碍最大运动表现。运动后,少尿和低钠血症在月经期最为明显。此外,钙和镁的静息尿量与正常雌激素和孕激素的周期性波动无关。在口服避孕药的女性中,水、矿物质和肌酐的静息排泄量均显著低于一般月经周期值(p<0.01),运动后盐和水的排出量进一步减少。基础钙和镁排泄率显著低于一般月经周期值(p<0.05)。服用避孕药者肾脏对水和盐的保留可能会影响肾脏的内环境稳定。矿物质潴留的后果尚不清楚。