Department of Convalescent Area, Ningbo Psychiatric Hospital, Ningbo 315040, China.
Department of Cadre Ward, 906 Hospital of the Chinese People's Liberation Army, Ningbo 315040, China.
Molecules. 2022 Jun 29;27(13):4175. doi: 10.3390/molecules27134175.
Alzheimer's disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.
阿尔茨海默病（AD）是一种进行性神经疾病。AD 的患病率不断上升，因此需要迅速开发有效的治疗方法。尽管进行了大量研究，但只有少数几种药物能够延缓疾病的发展。一些具有药理活性的物质来源于植物，通过靶向乙酰胆碱酯酶（AChE）、丁酰胆碱酯酶（BuChE）、β-分泌酶、γ-分泌酶和单胺氧化酶（MAO）等多种酶，已被证明对 AD 的治疗有积极作用，这些酶被认为是潜在的治疗靶点。药用植物已经为药物开发贡献了许多先导分子，其中许多正在进行临床试验。许多药用植物已被证明可以减轻 AD 相关的退行性症状，无论是在其原始形式还是作为分离的化合物。本综述的目的是简要概述 AD 及其当前的治疗方法，然后讨论作为治疗剂的天然化合物以及产生积极效果的相关过程，特别是 AD 的管理。
