硅胶固载硫酸对三乙基原甲酸酯催化胺的 - 甲酰化反应的性能。
Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for -Formylation of Amines with Triethyl Orthoformate.
机构信息
Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O Box 218, Pretoria 0204, South Africa.
出版信息
Molecules. 2022 Jun 30;27(13):4213. doi: 10.3390/molecules27134213.
In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for -formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (HSO-SiO). All reactions were performed in refluxing triethyl orthoformate (65 °C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.
在当前有机合成领域，寻找方便、绿色、实用的催化方法的过程中，我们采用硅胶固载硫酸（HSO-SiO）作为催化剂，实现了各种胺类化合物的 -甲酰化反应，该方法简单、绿色、高效。所有反应均在回流的原甲酸三乙酯（65°C）中进行。在 4 分钟至 2 小时内，以高至优异的收率得到了相应的甲酰胺产物。该方法具有反应时间短、产率高的优点。催化剂可回收利用，且催化效率无明显损失。
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