Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Int J Mol Sci. 2022 Aug 23;23(17):9529. doi: 10.3390/ijms23179529.
The application of immobilized sulfuric acid on silica gel (HSO-SiO) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst's low cost, and the catalyst's reusability.
硅胶固载硫酸（HSO-SiO）作为一种高效、可重复使用的固体催化剂，在苯甲酸、醛/酮和异氰化物的 Passerini 反应合成新型α-烷氧基甲酰胺衍生物中得到了探索。在水相介质中，在催化条件下，Passerini 加合物在 10 分钟内以高至优异的收率得到。该工艺的关键优点包括反应时间短、收率高、催化剂成本低和催化剂可重复使用。
