Department of Clinical Sciences Malmö, Lund University, 20213 Malmö, Sweden.
Department of Surgery, Skåne University Hospital, 20501 Malmö, Sweden.
Nutrients. 2022 Jun 22;14(13):2575. doi: 10.3390/nu14132575.
Zinc has been suggested to play a role in breast cancer progression; however, no previous study on zinc levels and the potential effect on breast cancer survival has been conducted. This study investigates recurrence-free survival (RFS), breast cancer-specific survival (BCSS) and overall survival (OS) in relation to zinc levels, in serum and diet, overall and stratified for phosphorus and selenium levels. The Malmö Diet and Cancer Study, a prospective population-based cohort in Sweden including 17,035 women, was used to identify breast cancer patients diagnosed in the period 1991-2013. Diet was assessed by a validated modified diet history method. A Cox regression analysis yielded hazard ratios (HRs) with 95% confidence intervals adjusted for potential confounders. Out of 1062 patients with invasive breast cancer, 268 recurrences, 205 breast cancer deaths and 228 deaths from other causes were recorded. No overall associations were seen between zinc and RFS, BCSS or OS. However, in women with a high phosphorus intake, a higher BCSS and OS were seen in zinc intake Q2 to Q4 versus Q1; the adjusted HR was 0.41 (0.23-0.73) and 0.64 (0.41-1.00), respectively. The results indicate that the combination of intermediate/high zinc intake and high phosphorus intake may lead to a better breast cancer survival.
锌被认为在乳腺癌的进展中发挥作用；然而，之前没有关于锌水平及其对乳腺癌生存潜在影响的研究。本研究调查了血清和饮食中锌水平与无复发生存（RFS）、乳腺癌特异性生存（BCSS）和总生存（OS）的关系，总体上并按磷和硒水平分层。使用来自瑞典的前瞻性基于人群的马尔默饮食与癌症研究（Malmö Diet and Cancer Study）来确定 1991-2013 年期间诊断出的乳腺癌患者。通过经过验证的改良饮食史方法评估饮食。Cox 回归分析得出了调整潜在混杂因素后的危险比（HR）和 95%置信区间。在 1062 名浸润性乳腺癌患者中，记录了 268 例复发、205 例乳腺癌死亡和 228 例其他原因死亡。锌与 RFS、BCSS 或 OS 之间没有总体关联。然而，在磷摄入量较高的女性中，锌摄入量 Q2 至 Q4 与 Q1 相比，BCSS 和 OS 更高；调整后的 HR 分别为 0.41（0.23-0.73）和 0.64（0.41-1.00）。结果表明，中/高锌摄入与高磷摄入的结合可能导致乳腺癌生存更好。
