Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Nutrients. 2023 Mar 31;15(7):1703. doi: 10.3390/nu15071703.
Breast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease continue to pose significant difficulties. New treatment approaches are therefore urgently required. Zinc is an important trace element that is involved in regulating various enzymatic, metabolic, and cellular processes in the human body. Several studies have shown that abnormal zinc homeostasis can lead to the onset and progression of various diseases, including breast cancer. This review highlights the role played by zinc transporters in pathogenesis, apoptosis, signal transduction, and potential clinical applications in breast cancer. Additionally, the translation of the clinical applications of zinc and associated molecules in breast cancer, as well as the recent developments in the zinc-related drug targets for breast cancer treatment, is discussed. These developments offer novel insights into understanding the concepts and approaches that could be used for the diagnosis and management of breast cancer.
乳腺癌已成为全球最常见的癌症。尽管在过去几十年中，通过化疗、内分泌治疗和免疫治疗的联合应用，在乳腺癌的治疗方面取得了重大进展，但该疾病的发生、治疗、复发和转移仍然存在很大的困难。因此，迫切需要新的治疗方法。锌是一种重要的微量元素，参与调节人体的各种酶、代谢和细胞过程。多项研究表明，锌稳态异常可导致多种疾病的发生和发展，包括乳腺癌。本综述重点介绍了锌转运体在乳腺癌发病机制、细胞凋亡、信号转导以及潜在的临床应用中的作用。此外，还讨论了锌及其相关分子在乳腺癌中的临床应用，以及最近在乳腺癌治疗中与锌相关的药物靶点的发展。这些进展为理解用于乳腺癌诊断和管理的概念和方法提供了新的思路。
