Department of Surgery, Skåne University Hospital Malmö, Lund University, 20501, Malmö, Sweden.
Cancer Causes Control. 2021 Aug;32(8):815-826. doi: 10.1007/s10552-021-01433-1. Epub 2021 Apr 29.
Selenium has been suggested to be protective against breast cancer, but the evidence remains inconclusive. Hence, it is important to further examine the potential protective effect. This prospective cohort study investigates pre-diagnostic selenium intake in relation to breast cancer risk. In addition, we analyze serum selenium as a marker of dietary intake.
This study includes 17,035 women in the Malmö Diet and Cancer cohort. Dietary assessment and serum samples were collected at baseline (1991-1996). During 344,584 person-years of follow-up, 1,427 incident cases were retrieved. Cox regression analysis examined breast cancer risks adjusted for potential confounding factors. In addition, odds ratios (ORs) were estimated for 1186 cases and an equal number of controls in relation to quartiles (Q) of selenium intake and groups consisting of a combination of intake and serum selenium levels.
No overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk was found. The adjusted relative risk for breast cancer in selenium intake Q4 versus Q1 was 0.96 (0.83-1.12) (P = 0.65). Similarly, adjusted the OR for breast cancer in selenium intake for Q4 versus Q1 was 0.97 (0.76-1.23). The kappa value, 0.096 (p = 0.001), showed poor agreement between serum selenium and selenium intake.
Our findings suggest that there is no overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk. Finally, our results showed a poor correlation between estimated selenium intake and serum selenium.
有研究表明，硒对预防乳腺癌具有保护作用，但证据仍不明确。因此，进一步研究其潜在的保护作用很重要。本前瞻性队列研究调查了诊断前硒摄入与乳腺癌风险的关系。此外，我们还分析了血清硒作为膳食摄入标志物的情况。
本研究纳入了马尔默饮食与癌症队列中的 17035 名女性。在基线（1991-1996 年）时收集了饮食评估和血清样本。在 344584 人年的随访期间，共发现了 1427 例乳腺癌新发病例。Cox 回归分析调整了潜在混杂因素后，考察了乳腺癌风险与硒摄入的关系。此外，还根据硒摄入量的四分位（Q）和由摄入与血清硒水平相结合的组，估计了 1186 例病例和相同数量的对照者的比值比（OR）。
未发现硒摄入或摄入与血清水平的组合与乳腺癌风险之间存在总体关联。与 Q1 相比，Q4 硒摄入量的乳腺癌调整相对风险为 0.96（0.83-1.12）（P=0.65）。同样，与 Q1 相比，Q4 硒摄入量的乳腺癌调整 OR 为 0.97（0.76-1.23）。kappa 值为 0.096（p=0.001），表明血清硒与硒摄入之间的一致性较差。
我们的研究结果表明，硒摄入或摄入与血清水平的组合与乳腺癌风险之间没有总体关联。最后，我们的结果显示，估计的硒摄入与血清硒之间相关性较差。
