State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Nutrients. 2022 Jun 25;14(13):2636. doi: 10.3390/nu14132636.
Liver injury caused by an overdose of acetaminophen (APAP) is a major public health problem. This study aimed to evaluate the effects of polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver's detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP-induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.
过量服用对乙酰氨基酚（APAP）导致的肝损伤是一个重大的公共卫生问题。本研究旨在评估多糖（BPP）对 APAP 诱导的肝损伤和肠道菌群的影响。结果表明，BPP 可以预防 APAP 诱导的肝损伤，减轻肝细胞凋亡，提高抗氧化能力，增强肝脏对 APAP 的解毒能力。同时，BPP 改善了 APAP 引起的肠道菌群失调。更重要的是，我们发现 BPP 在小鼠肠道菌群耗竭后其肝保护作用消失。此外，我们通过粪便微生物群移植重建了小鼠的肠道菌群结构，发现有效缓解了 APAP 诱导的肝损伤症状。总的来说，BPP 是一种有潜力的肝保护药物，可预防 APAP 诱导的肝损伤，可能是通过肠道菌群介导的。
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