Digestive Disease Center, Changbing Show-Chwan Memorial Hospital, Lukang 50544, Taiwan.
Department of Food Science and Technology, Hungkuang University, Taichung 43302, Taiwan.
Nutrients. 2022 Jun 29;14(13):2720. doi: 10.3390/nu14132720.
(1) Background: The association of sugar-sweetened beverages (SSBs) with cardiovascular disease (CVD) mortality in younger adults (age 20−39) is rarely mentioned in the literature. Younger adults are less vulnerable to CVDs, but they tend to consume more SSBs. This prospective study aimed to assess the association between CVD mortality and SSBs in younger adults between 1994 and 2017. (2) Methods: The cohort enrolled 288,747 participants consisting of 139,413 men and 148,355 women, with a mean age 30.6 ± 4.8 years, from a health surveillance program. SSBs referred to any drink with real sugar added, such as fructose corn syrup or sucrose. One serving of SSB contains about 150 Kcal of sugar in 12 oz of drink. Cox models were used to estimate the mortality risk. (3) Results: There were 391 deaths from CVDs in the younger adults, and the positive association with CVD mortality started when SSB intake was ≥2 servings/day (HR: 1.59, 95% CI: 1.16−2.17). With mortalities from diabetes and kidney disease added to CVDs, the so-called expanded CVD mortality risk was 1.49 (95% CI: 1.11−2.01). By excluding CVD risk factors (hypertension, diabetes, and smoking), the CVD mortality risk increased to 2.48 (95% CI: 1.33−4.62). The dose−response relationship persisted (p < 0.05 for trend) in every model above. (4) Conclusions: Higher intake of SSBs (≥2 servings/day) was associated with increased CVD mortality in younger adults. The younger adults (age 20−39) with SSB intake ≥2 servings/day had a 50% increase in CVD mortality in our study, and the mortality risk increased up to 2.5 times for those without CVD risk factors. The dose−response relationship between the quantity of SSB intake and the mortality risk of CVD in younger adults discourages SSB intake for the prevention of CVD mortality.
（1）背景：含糖饮料（SSB）与心血管疾病（CVD）死亡率之间的关联在年轻成年人（年龄 20-39 岁）中的文献中很少提及。年轻成年人不易患 CVD，但他们往往会消费更多的 SSB。本前瞻性研究旨在评估 1994 年至 2017 年期间年轻成年人 CVD 死亡率与 SSB 之间的关系。
（2）方法：该队列纳入了 288747 名参与者，其中包括 139413 名男性和 148355 名女性，平均年龄为 30.6±4.8 岁，来自健康监测计划。SSB 是指添加了真正糖的任何饮料，如果葡糖浆或蔗糖。一份 SSB 饮料含有约 150 卡路里的糖，为 12 盎司。使用 Cox 模型估计死亡率风险。
（3）结果：年轻成年人中有 391 人死于 CVD，当 SSB 摄入量≥2 份/天时，与 CVD 死亡率呈正相关（HR：1.59，95%CI：1.16-2.17）。将糖尿病和肾脏疾病的死亡率加入 CVD 后，所谓的扩展 CVD 死亡率风险为 1.49（95%CI：1.11-2.01）。排除 CVD 危险因素（高血压、糖尿病和吸烟）后，CVD 死亡率风险增加到 2.48（95%CI：1.33-4.62）。在上述每个模型中，剂量-反应关系均持续存在（趋势 p<0.05）。
（4）结论：较高的 SSB 摄入量（≥2 份/天）与年轻成年人 CVD 死亡率增加相关。在我们的研究中，SSB 摄入量≥2 份/天的年轻成年人 CVD 死亡率增加 50%，而无 CVD 危险因素的成年人死亡率风险增加至 2.5 倍。年轻成年人 SSB 摄入量与 CVD 死亡率之间的剂量-反应关系不利于 SSB 摄入量以预防 CVD 死亡率。
