Arumugam Gowri Manohari, Karunakaran Santhosh Kumar, Galian Raquel E, Pérez-Prieto Julia
Instituto de Ciencia Molecular (ICMol), University of Valencia, Catedrático José Beltrán, 2, Paterna, 46980 Valencia, Spain.
State Key Laboratory of Optoelectronic Materials and Technologies, Nanotechnology Research Center, School of Materials Science & Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Nanomaterials (Basel). 2022 Jun 21;12(13):2130. doi: 10.3390/nano12132130.
All-inorganic lead halide perovskite nanocrystals have great potential in optoelectronics and photovoltaics. However, their biological applications have not been explored much owing to their poor stability and shallow penetration depth of ultraviolet (UV) excitation light into tissues. Interestingly, the combination of all-inorganic halide perovskite nanocrystals (IHP NCs) with nanoparticles consisting of lanthanide-doped matrix (Ln NPs, such as NaYF:Yb,Er NPs) is stable, near-infrared (NIR) excitable and emission tuneable (up-shifting emission), all of them desirable properties for biological applications. In addition, luminescence in inorganic perovskite nanomaterials has recently been sensitized via lanthanide doping. In this review, we discuss the progress of various Ln-doped all-inorganic halide perovskites (LnIHP). The unique properties of nanoheterostructures based on the interaction between IHP NCs and Ln NPs as well as those of LnIHP NCs are also detailed. Moreover, a systematic discussion of basic principles and mechanisms as well as of the recent advancements in bio-imaging based on these materials are presented. Finally, the challenges and future perspectives of bio-imaging based on NIR-triggered sensitized luminescence of IHP NCs are discussed.
全无机铅卤化物钙钛矿纳米晶体在光电子学和光伏领域具有巨大潜力。然而，由于其稳定性差以及紫外（UV）激发光在组织中的穿透深度浅，它们的生物应用尚未得到充分探索。有趣的是，全无机卤化物钙钛矿纳米晶体（IHP NCs）与由镧系元素掺杂基质组成的纳米颗粒（Ln NPs，如NaYF:Yb,Er NPs）的组合具有稳定性、近红外（NIR）可激发性和发射可调性（上转换发射），所有这些都是生物应用中理想的特性。此外，最近通过镧系元素掺杂使无机钙钛矿纳米材料中的发光得到了敏化。在本综述中，我们讨论了各种镧系元素掺杂的全无机卤化物钙钛矿（LnIHP）的进展。还详细介绍了基于IHP NCs与Ln NPs之间相互作用的纳米异质结构以及LnIHP NCs的独特性质。此外，还对基于这些材料的生物成像的基本原理和机制以及最新进展进行了系统讨论。最后，讨论了基于IHP NCs的近红外触发敏化发光的生物成像面临的挑战和未来前景。
