Kuwano R, Usui H, Maeda T, Araki K, Yamakuni T, Kurihara T, Takahashi Y
Brain Res. 1987 Apr;388(1):79-82.
Using Southern blot analysis it is demonstrated that S-100 alpha and beta genes were found as single copies in the rat genome. S-100 alpha mRNA was not found at all in rat brain during the developmental period, but it was slightly detectable in muscle and kidney. S-100 beta mRNA was detected in rat brain, and its mRNA level increased during the developmental period. The different localizations of the subunits may be due to the specific expression of each gene in various tissues.
通过Southern印迹分析表明，在大鼠基因组中，S-100α和β基因以单拷贝形式存在。在发育期间，大鼠脑中完全未检测到S-100α mRNA，但在肌肉和肾脏中可略微检测到。在大鼠脑中检测到了S-100β mRNA，并且其mRNA水平在发育期间有所增加。亚基的不同定位可能是由于每个基因在各种组织中的特异性表达所致。
