Davenne D, Adrien J
Brain Res. 1987 Apr 14;409(1):1-9. doi: 10.1016/0006-8993(87)90735-9.
Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Whereas the states of vigilance remained normal, a significant reduction of the unitary discharge in the LGN during paradoxical sleep (PS) and particularly of its phasic component, was observed concomitantly with the suppression of PGO waves. It is concluded that phasic discharge of LGN neurons during PS is controlled by PGO-related mechanisms and that its suppression during the developmental period provides a model for studying its significance on brain maturation.
通过对小猫进行双侧中脑的膝状体-脑桥-膝状体-枕叶（PGO）通路损伤，实现了对PGO波的抑制。然后在损伤后的一个月内，长期记录睡眠-觉醒参数以及外侧膝状体核（LGN）中的自发单位活动。尽管警觉状态保持正常，但在快速眼动睡眠（PS）期间，LGN中的单位放电显著减少，尤其是其相位成分，这与PGO波的抑制同时出现。得出的结论是，PS期间LGN神经元的相位放电受与PGO相关的机制控制，并且在发育期间对其抑制为研究其对大脑成熟的意义提供了一个模型。
