Abdullah Turdimuhammad, Qurban Rayyan O, Abdel-Wahab Mohamed Sh, Salah Numan A, Melaibari Ammar AbdulGhani, Zamzami Mazin A, Memić Adnan
Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2022 Jun 29;14(13):2645. doi: 10.3390/polym14132645.
Three-dimensional (3D) printing is one of the most futuristic manufacturing technologies, allowing on-demand manufacturing of products with highly complex geometries and tunable material properties. Among the different 3D-printing technologies, fused deposition modeling (FDM) is the most popular one due to its affordability, adaptability, and pertinency in many areas, including the biomedical field. Yet, only limited amounts of materials are commercially available for FDM, which hampers their application potential. Polybutylene succinate (PBS) is one of the biocompatible and biodegradable thermoplastics that could be subjected to FDM printing for healthcare applications. However, microbial contamination and the formation of biofilms is a critical issue during direct usage of thermoplastics, including PBS. Herein, we developed a composite filament containing polybutylene succinate (PBS) and lignin for FDM printing. Compared to pure PBS, the PBS/lignin composite with 2.5~3.5% lignin showed better printability and antioxidant and antimicrobial properties. We further coated silver/zinc oxide on the printed graft to enhance their antimicrobial performance and obtain the strain-specific antimicrobial activity. We expect that the developed approach can be used in biomedical applications such as patient-specific orthoses.
三维（3D）打印是最具未来感的制造技术之一，能够按需制造具有高度复杂几何形状和可调材料特性的产品。在不同的3D打印技术中，熔融沉积建模（FDM）因其在包括生物医学领域在内的许多领域的经济性、适应性和针对性而成为最受欢迎的一种。然而，可用于FDM的商业材料数量有限，这限制了它们的应用潜力。聚丁二酸丁二醇酯（PBS）是一种生物相容且可生物降解的热塑性塑料，可用于FDM打印以用于医疗保健应用。然而，微生物污染和生物膜的形成是热塑性塑料（包括PBS）直接使用过程中的一个关键问题。在此，我们开发了一种用于FDM打印的含聚丁二酸丁二醇酯（PBS）和木质素的复合长丝。与纯PBS相比，含有2.5~3.5%木质素的PBS/木质素复合材料表现出更好的可打印性、抗氧化和抗菌性能。我们进一步在打印的移植物上涂覆银/氧化锌以增强其抗菌性能并获得菌株特异性抗菌活性。我们期望所开发的方法可用于生物医学应用，如定制的矫形器。
