Cognitive Science Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.
Department of Human-Computer Interaction, Hanyang University, Ansan, Republic of Korea.
J Int Med Res. 2022 Jul;50(7):3000605221109789. doi: 10.1177/03000605221109789.
Although serotonergic dysfunction is significantly associated with major depressive disorder (MDD) and schizophrenia (SCZ), comparison of serotonergic dysfunction in both diseases has received little attention. Serotonin hypotheses have suggested diminished and elevated serotonin activity in MDD and SCZ, respectively. However, the foundations underlying these hypotheses are unclear regarding changes in serotonin neurotransmission in the aging brain. The loudness dependence of auditory evoked potentials (LDAEP) reflects serotonin neurotransmission. The present study compared the LDAEP between patients with SCZ or MDD and healthy controls (HCs). We further examined whether age was correlated with the LDAEP and clinical symptoms.
This prospective clinical study included 105 patients with SCZ (n = 54) or MDD (n = 51). Additionally, 35 HCs were recruited for this study. The LDAEP was measured on the midline channels via 62 electroencephalography channels.
Patients with SCZ or MDD showed a significantly smaller mean LDAEP than those in HCs. The LDAEP was positively correlated with age in patients with SCZ or MDD.
Changes in central serotonergic activity could be indicated by evaluating the LDAEP in patients with SCZ or MDD. Age-related reductions in serotonergic activity may be screened using the LDAEP in patients with SCZ or MDD.
尽管 5-羟色胺能功能障碍与重度抑郁症（MDD）和精神分裂症（SCZ）显著相关，但这两种疾病中 5-羟色胺能功能障碍的比较却很少受到关注。5-羟色胺假说分别提出 MDD 和 SCZ 中 5-羟色胺活性降低和升高。然而，关于衰老大脑中 5-羟色胺神经传递的变化，这些假说的基础尚不清楚。听觉诱发电位的响度依赖性（LDAEP）反映了 5-羟色胺神经传递。本研究比较了 SCZ 或 MDD 患者与健康对照者（HCs）之间的 LDAEP。我们进一步研究了年龄是否与 LDAEP 和临床症状相关。
这是一项前瞻性临床研究，纳入了 105 例 SCZ 患者（n=54）或 MDD 患者（n=51）。此外，还招募了 35 名 HCs 参加本研究。通过 62 个脑电图通道在中线通道上测量 LDAEP。
与 HCs 相比，SCZ 或 MDD 患者的平均 LDAEP 明显较小。LDAEP 与 SCZ 或 MDD 患者的年龄呈正相关。
通过评估 SCZ 或 MDD 患者的 LDAEP，可以指示中枢 5-羟色胺活性的变化。在 SCZ 或 MDD 患者中，可以使用 LDAEP 筛选与年龄相关的 5-羟色胺活性降低。
